"Phorbol 12,13-Dibutyrate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.
Descriptor ID |
D015240
|
MeSH Number(s) |
D02.455.849.291.500.510.700
|
Concept/Terms |
Phorbol 12,13-Dibutyrate- Phorbol 12,13-Dibutyrate
- 12,13-Dibutyrate, Phorbol
- Phorbol-12,13-Dibutyrate
- Phorbol 12,13 Dibutyrate
|
Below are MeSH descriptors whose meaning is more general than "Phorbol 12,13-Dibutyrate".
Below are MeSH descriptors whose meaning is more specific than "Phorbol 12,13-Dibutyrate".
This graph shows the total number of publications written about "Phorbol 12,13-Dibutyrate" by people in this website by year, and whether "Phorbol 12,13-Dibutyrate" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
1994 | 0 | 1 | 1 |
1995 | 0 | 2 | 2 |
1996 | 1 | 0 | 1 |
1999 | 0 | 1 | 1 |
2000 | 0 | 1 | 1 |
2011 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Phorbol 12,13-Dibutyrate" by people in Profiles.
-
Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G317-25.
-
Effects of sphingosine and other sphingolipids on protein kinase C. Methods Enzymol. 2000; 312:361-73.
-
Protein kinase C-delta is a target of B-cell antigen receptor signaling. Immunol Lett. 1999 Aug 03; 69(2):259-67.
-
Biological activity of 26-succinylbryostatin 1. Biochim Biophys Acta. 1996 Jul 24; 1312(3):197-206.
-
Effects of modulators of protein kinases on taxol-induced apoptosis of human leukemic cells possessing disparate levels of p26BCL-2 protein. Clin Cancer Res. 1995 Nov; 1(11):1399-406.
-
Agonist-induced desensitization and phosphorylation of human 5-HT1A receptor expressed in Sf9 insect cells. Biochemistry. 1995 Sep 19; 34(37):11954-62.
-
Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets. J Biol Chem. 1994 Apr 01; 269(13):9729-35.
-
Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25; 268(21):15958-64.
-
Selective activation of p42 mitogen-activated protein (MAP) kinase in murine B lymphoma cell lines by membrane immunoglobulin cross-linking. Evidence for protein kinase C-independent and -dependent mechanisms of activation. Biochem J. 1992 Oct 01; 287 ( Pt 1):269-76.
-
Delayed accumulation of diacylglycerol in platelets as a mechanism for regulation of onset of aggregation and secretion. Blood. 1991 Jul 15; 78(2):435-44.