GTP-Binding Protein alpha Subunit, Gi2
"GTP-Binding Protein alpha Subunit, Gi2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A PERTUSSIS TOXIN-sensitive GTP-binding protein alpha subunit. It couples with a variety of CELL SURFACE RECEPTORS, has been implicated in INTERLEUKIN-12 production, and may play a role in INFLAMMATORY BOWEL DISEASES.
| Descriptor ID |
D051960
|
| MeSH Number(s) |
D08.811.277.040.330.300.200.100.200.500 D12.644.360.360.100.200.500 D12.776.157.325.332.100.200.500 D12.776.476.375.100.200.500 D12.776.543.325.100.200.500
|
| Concept/Terms |
GTP-Binding Protein alpha Subunit, Gi2- GTP-Binding Protein alpha Subunit, Gi2
- GTP Binding Protein alpha Subunit, Gi2
- Galphai2 Protein
- Gi2-alpha Protein
- Gi2 alpha Protein
- G Protein Subunit alpha I2
- Galpha(i2) Protein
|
Below are MeSH descriptors whose meaning is more general than "GTP-Binding Protein alpha Subunit, Gi2".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Acid Anhydride Hydrolases [D08.811.277.040]
- GTP Phosphohydrolases [D08.811.277.040.330]
- GTP-Binding Proteins [D08.811.277.040.330.300]
- Heterotrimeric GTP-Binding Proteins [D08.811.277.040.330.300.200]
- GTP-Binding Protein alpha Subunits [D08.811.277.040.330.300.200.100]
- GTP-Binding Protein alpha Subunits, Gi-Go [D08.811.277.040.330.300.200.100.200]
- GTP-Binding Protein alpha Subunit, Gi2 [D08.811.277.040.330.300.200.100.200.500]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Heterotrimeric GTP-Binding Proteins [D12.644.360.360]
- GTP-Binding Protein alpha Subunits [D12.644.360.360.100]
- GTP-Binding Protein alpha Subunits, Gi-Go [D12.644.360.360.100.200]
- GTP-Binding Protein alpha Subunit, Gi2 [D12.644.360.360.100.200.500]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- GTP-Binding Proteins [D12.776.157.325]
- Heterotrimeric GTP-Binding Proteins [D12.776.157.325.332]
- GTP-Binding Protein alpha Subunits [D12.776.157.325.332.100]
- GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.157.325.332.100.200]
- GTP-Binding Protein alpha Subunit, Gi2 [D12.776.157.325.332.100.200.500]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Heterotrimeric GTP-Binding Proteins [D12.776.476.375]
- GTP-Binding Protein alpha Subunits [D12.776.476.375.100]
- GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.476.375.100.200]
- GTP-Binding Protein alpha Subunit, Gi2 [D12.776.476.375.100.200.500]
- Membrane Proteins [D12.776.543]
- Heterotrimeric GTP-Binding Proteins [D12.776.543.325]
- GTP-Binding Protein alpha Subunits [D12.776.543.325.100]
- GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.543.325.100.200]
- GTP-Binding Protein alpha Subunit, Gi2 [D12.776.543.325.100.200.500]
Below are MeSH descriptors whose meaning is more specific than "GTP-Binding Protein alpha Subunit, Gi2".
This graph shows the total number of publications written about "GTP-Binding Protein alpha Subunit, Gi2" by people in this website by year, and whether "GTP-Binding Protein alpha Subunit, Gi2" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "GTP-Binding Protein alpha Subunit, Gi2" by people in Profiles.
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Gai2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination. J Immunol. 2019 03 01; 202(5):1510-1520.
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Direct Coupling of a Seven-Transmembrane-Span Receptor to a Gai G-Protein Regulatory Motif Complex. Mol Pharmacol. 2015 Aug; 88(2):231-7.
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Suppression of GNAI2 message in ovarian cancer. J Ovarian Res. 2014 Jan 14; 7:6.
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Toll-like receptor-induced inflammatory cytokines are suppressed by gain of function or overexpression of Ga(i2) protein. Inflammation. 2012 Oct; 35(5):1611-7.
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Heterotrimeric Ga(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis. Biochim Biophys Acta. 2011 Mar; 1813(3):466-72.
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Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins. Biochim Biophys Acta. 2006 Oct; 1763(10):1051-8.
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Signal transduction events in Chinese hamster ovary cells expressing human CD14; effect of endotoxin desensitization. Shock. 2001 Apr; 15(4):291-6.