14-3-3 Proteins

"14-3-3 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.

Descriptor ID	D048948
MeSH Number(s)	D12.644.360.024.050 D12.776.157.057.002 D12.776.476.024.050
Concept/Terms	14-3-3 Proteins 14-3-3 Proteins 14 3 3 Proteins 14-3-3 Protein 14 3 3 Protein Brain 14-3-3 Protein 14-3-3 Protein, Brain Brain 14 3 3 Protein Protein 14-3-3 14-3-3 Protein, tau Isoform 14-3-3 Protein, tau Isoform 14 3 3 Protein, tau Isoform 14-3-3tau Protein 14 3 3tau Protein Protein, 14-3-3tau 14-3-3 tau Protein 14 3 3 tau Protein 14-3-3 Protein, zeta Isoform 14-3-3 Protein, zeta Isoform 14 3 3 Protein, zeta Isoform 14-3-3zeta Protein 14 3 3zeta Protein 14-3-3 zeta Protein 14 3 3 zeta Protein 14-3-3 Protein, eta Isoform 14-3-3 Protein, eta Isoform 14 3 3 Protein, eta Isoform 14-3-3eta Protein 14 3 3eta Protein 14-3-3 eta Protein 14 3 3 eta Protein eta Protein, 14-3-3 14-3-3 Protein, epsilon Isoform 14-3-3 Protein, epsilon Isoform 14 3 3 Protein, epsilon Isoform 14-3-3 epsilon Protein 14 3 3 epsilon Protein 14-3-3epsilon Protein 14 3 3epsilon Protein 14-3-3 Protein, gamma Isoform 14-3-3 Protein, gamma Isoform 14 3 3 Protein, gamma Isoform 14-3-3gamma Protein 14 3 3gamma Protein 14-3-3 gamma Protein 14 3 3 gamma Protein 14-3-3 Protein, beta Isoform 14-3-3 Protein, beta Isoform 14 3 3 Protein, beta Isoform 14-3-3beta Protein 14 3 3beta Protein 14-3-3 beta Protein 14 3 3 beta Protein

Below are MeSH descriptors whose meaning is more general than "14-3-3 Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
14-3-3 Proteins [D12.644.360.024.050]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
14-3-3 Proteins [D12.776.157.057.002]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
14-3-3 Proteins [D12.776.476.024.050]

Below are MeSH descriptors whose meaning is related to "14-3-3 Proteins".

Below are MeSH descriptors whose meaning is more specific than "14-3-3 Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "14-3-3 Proteins" by people in this website by year, and whether "14-3-3 Proteins" was a major or minor topic of these publications.

Bar chart showing 9 publications over 7 distinct years, with a maximum of 2 publications in 2005 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	1	2
2006	1	0	1
2010	1	0	1
2012	0	1	1
2013	2	0	2
2015	0	1	1
2021	1	0	1

Below are the most recent publications written about "14-3-3 Proteins" by people in Profiles.

Chan TY, Egbert CM, Maxson JE, Siddiqui A, Larsen LJ, Kohler K, Balasooriya ER, Pennington KL, Tsang TM, Frey M, Soderblom EJ, Geng H, Müschen M, Forostyan TV, Free S, Mercenne G, Banks CJ, Valdoz J, Whatcott CJ, Foulks JM, Bearss DJ, O'Hare T, Huang DCS, Christensen KA, Moody J, Warner SL, Tyner JW, Andersen JL. TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. Nat Commun. 2021 09 09; 12(1):5337.

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Liu P, Gan W, Guo C, Xie A, Gao D, Guo J, Zhang J, Willis N, Su A, Asara JM, Scully R, Wei W. Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair. Mol Cell. 2015 Feb 19; 57(4):648-661.

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Helke KL, Queen SE, Mankowski JL. 14-3-3 Protein in CSF reflects SIV-mediated pre-synaptic damage. Curr HIV Res. 2013 Jun; 11(4):281-7.

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Ngok SP, Geyer R, Kourtidis A, Storz P, Anastasiadis PZ. Phosphorylation-mediated 14-3-3 protein binding regulates the function of the rho-specific guanine nucleotide exchange factor (RhoGEF) Syx. J Biol Chem. 2013 Mar 01; 288(9):6640-50.

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Kim Y, Ignatchenko V, Yao CQ, Kalatskaya I, Nyalwidhe JO, Lance RS, Gramolini AO, Troyer DA, Stein LD, Boutros PC, Medin JA, Semmes OJ, Drake RR, Kislinger T. Identification of differentially expressed proteins in direct expressed prostatic secretions of men with organ-confined versus extracapsular prostate cancer. Mol Cell Proteomics. 2012 Dec; 11(12):1870-84.

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Barbash O, Lee EK, Diehl JA. Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3?. Oncogene. 2011 Apr 28; 30(17):1995-2002.

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Pavlov TS, Chahdi A, Ilatovskaya DV, Levchenko V, Vandewalle A, Pochynyuk O, Sorokin A, Staruschenko A. Endothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2. J Am Soc Nephrol. 2010 May; 21(5):833-43.

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Bronisz A, Sharma SM, Hu R, Godlewski J, Tzivion G, Mansky KC, Ostrowski MC. Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors. Mol Biol Cell. 2006 Sep; 17(9):3897-906.

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Qi XJ, Wildey GM, Howe PH. Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function. J Biol Chem. 2006 Jan 13; 281(2):813-23.

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Helke KL, Queen SE, Tarwater PM, Turchan-Cholewo J, Nath A, Zink MC, Irani DN, Mankowski JL. 14-3-3 protein in CSF: an early predictor of SIV CNS disease. J Neuropathol Exp Neurol. 2005 Mar; 64(3):202-8.

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