Complement Factor B

"Complement Factor B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A glycine-rich, heat-labile serum glycoprotein that contains a component of the C3 CONVERTASE ALTERNATE PATHWAY (C3bBb). Bb, a serine protease, is generated when factor B is cleaved by COMPLEMENT FACTOR D into Ba and Bb.

Descriptor ID	D011415
MeSH Number(s)	D08.622.200 D08.811.277.656.300.760.198 D08.811.277.656.959.350.198 D12.776.124.486.274.900
Concept/Terms	Complement Factor B Complement Factor B Factor B, Complement C3 Proactivator Proactivator, C3 C3PA Complement 3 Proactivator Proactivator, Complement 3 Factor B Complement Protein B Protein B, Complement Complement Protein Factor B Properdin Factor B Factor B, Properdin Complement Factor B, Alternative Pathway Complement Factor Bb Complement Factor Bb Bb, Complement Factor Factor Bb, Complement Properdin Factor Bb Factor Bb, Properdin Complement Factor B-Derived Fragment Bb Complement Factor B Derived Fragment Bb Bb Fragment of Factor B Complement Factor B Fragment, Bb Properdin Factor Bf F1 Properdin Factor Bf F1 Properdin Factor Bf Properdin Factor Bf Factor Bf, Properdin Complement Factor Ba Complement Factor Ba Factor Ba, Complement Properdin Factor Ba Factor Ba, Properdin

Below are MeSH descriptors whose meaning is more general than "Complement Factor B".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzyme Precursors [D08.622]
Complement Factor B [D08.622.200]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Serine Endopeptidases [D08.811.277.656.300.760]
Complement Factor B [D08.811.277.656.300.760.198]
Serine Proteases [D08.811.277.656.959]
Serine Endopeptidases [D08.811.277.656.959.350]
Complement Factor B [D08.811.277.656.959.350.198]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Complement System Proteins [D12.776.124.486.274]
Complement Factor B [D12.776.124.486.274.900]

Below are MeSH descriptors whose meaning is related to "Complement Factor B".

Below are MeSH descriptors whose meaning is more specific than "Complement Factor B".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Complement Factor B" by people in this website by year, and whether "Complement Factor B" was a major or minor topic of these publications.

Bar chart showing 11 publications over 9 distinct years, with a maximum of 2 publications in 2000 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	2	0	2
2003	1	0	1
2005	0	1	1
2007	1	0	1
2010	0	1	1
2012	0	2	2
2014	0	1	1
2015	1	0	1
2019	0	1	1

Below are the most recent publications written about "Complement Factor B" by people in Profiles.

Rohrer B, Frazer-Abel A, Leonard A, Ratnapriya R, Ward T, Pietraszkiewicz A, O'Quinn E, Adams K, Swaroop A, Wolf BJ. Association of age-related macular degeneration with complement activation products, smoking, and single nucleotide polymorphisms in South Carolinians of European and African descent. Mol Vis. 2019; 25:79-92.

View in: PubMed
Schnabolk G, Coughlin B, Joseph K, Kunchithapautham K, Bandyopadhyay M, O'Quinn EC, Nowling T, Rohrer B. Local production of the alternative pathway component factor B is sufficient to promote laser-induced choroidal neovascularization. Invest Ophthalmol Vis Sci. 2015 Jan 15; 56(3):1850-63.

View in: PubMed
Kunchithapautham K, Atkinson C, Rohrer B. Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation. J Biol Chem. 2014 May 23; 289(21):14534-46.

View in: PubMed
Elvington A, Atkinson C, Zhu H, Yu J, Takahashi K, Stahl GL, Kindy MS, Tomlinson S. The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol. 2012 Nov 01; 189(9):4640-7.

View in: PubMed
Ramos TN, Darley MM, Weckbach S, Stahel PF, Tomlinson S, Barnum SR. The C5 convertase is not required for activation of the terminal complement pathway in murine experimental cerebral malaria. J Biol Chem. 2012 Jul 13; 287(29):24734-8.

View in: PubMed
Davis KS, Casey SE, Mulligan JK, Mulligan RM, Schlosser RJ, Atkinson C. Murine complement deficiency ameliorates acute cigarette smoke-induced nasal damage. Otolaryngol Head Neck Surg. 2010 Jul; 143(1):152-8.

View in: PubMed
Alexander JJ, Jacob A, Vezina P, Sekine H, Gilkeson GS, Quigg RJ. Absence of functional alternative complement pathway alleviates lupus cerebritis. Eur J Immunol. 2007 Jun; 37(6):1691-701.

View in: PubMed
Thurman JM, Kraus DM, Girardi G, Hourcade D, Kang HJ, Royer PA, Mitchell LM, Giclas PC, Salmon J, Gilkeson G, Holers VM. A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in mice. Mol Immunol. 2005 Jan; 42(1):87-97.

View in: PubMed
Thurman JM, Ljubanovic D, Edelstein CL, Gilkeson GS, Holers VM. Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice. J Immunol. 2003 Feb 01; 170(3):1517-23.

View in: PubMed
Nataf S, Carroll SL, Wetsel RA, Szalai AJ, Barnum SR. Attenuation of experimental autoimmune demyelination in complement-deficient mice. J Immunol. 2000 Nov 15; 165(10):5867-73.

View in: PubMed

People

Explore

Similar Concepts

Top Journals