"Activin Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.
| Descriptor ID |
D029404
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.062 D12.776.543.750.750.400.820.500
|
| Concept/Terms |
Activin Receptors- Activin Receptors
- Receptor, Activin
- Activin Receptor-Like Kinases
- Activin Receptor like Kinases
- Kinases, Activin Receptor-like
- Receptor-like Kinases, Activin
- Activin Receptor
- Activin Receptor-like Kinase
- Activin Receptor like Kinase
- Kinase, Activin Receptor-like
- Receptor-like Kinase, Activin
|
Below are MeSH descriptors whose meaning is more general than "Activin Receptors".
Below are MeSH descriptors whose meaning is more specific than "Activin Receptors".
This graph shows the total number of publications written about "Activin Receptors" by people in this website by year, and whether "Activin Receptors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
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Below are the most recent publications written about "Activin Receptors" by people in Profiles.
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Left-right lineage analysis of the embryonic Xenopus heart reveals a novel framework linking congenital cardiac defects and laterality disease. Development. 2006 Apr; 133(7):1399-410.
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Left-right lineage analysis of AV cushion tissue in normal and laterality defective Xenopus hearts. Anat Rec A Discov Mol Cell Evol Biol. 2005 Dec; 287(2):1176-82.
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Developmental analysis of activin-like kinase receptor-4 (ALK4) expression in Xenopus laevis. Dev Dyn. 2005 Feb; 232(2):393-8.
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ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus. Dev Biol. 2004 Apr 15; 268(2):280-94.
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Activin family members in the developing chick retina: expression patterns, protein distribution, and in vitro effects. Dev Biol. 1999 Jun 01; 210(1):107-23.