Receptor-Interacting Protein Serine-Threonine Kinases
                             
                            
                            
                                
                            
                            
                                
                            
                            
                            
                                
                                    
                                            
	"Receptor-Interacting Protein Serine-Threonine Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, 
	MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, 
	which enables searching at various levels of specificity.
	
	
		
			
			
				A family of serine-threonine kinases that plays a role in intracellular signal transduction by interacting with a variety of signaling adaptor proteins such as CRADD SIGNALING ADAPTOR PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; and TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN. Although they were initially described as death domain-binding adaptor proteins, members of this family may contain other protein-binding domains such as those involving caspase activation and recruitment.
    
			
			
				
				
					
						| Descriptor ID | 
										
							D053422
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						| MeSH Number(s) | 
						
							 D08.811.913.696.620.682.700.801 D12.644.360.024.285.400 D12.644.360.024.500.186 D12.644.360.075.421.400 D12.776.157.057.018.400 D12.776.157.057.500.186 D12.776.476.024.320.662 D12.776.476.024.500.186 D12.776.476.075.421.400 
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						| Concept/Terms | 
						
							Receptor-Interacting Protein Serine-Threonine Kinases- Receptor-Interacting Protein Serine-Threonine Kinases
 - Receptor Interacting Protein Serine Threonine Kinases
 - RIP Serine-Threonine Kinases
 - Kinases, RIP Serine-Threonine
 - RIP Serine Threonine Kinases
 - Serine-Threonine Kinases, RIP
 
  Receptor-Interacting Protein Serine-Threonine Kinase 1- Receptor-Interacting Protein Serine-Threonine Kinase 1
 - Receptor Interacting Protein Serine Threonine Kinase 1
 - Receptor Interacting Protein RIP
 - RIP Serine-Threonine Kinase
 - Kinase, RIP Serine-Threonine
 - RIP Serine Threonine Kinase
 - Serine-Threonine Kinase, RIP
 - RIP (Receptor Interacting Protein)
 
  
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				Below are MeSH descriptors whose meaning is more general than "Receptor-Interacting Protein Serine-Threonine Kinases".
				
			 
			
			
				Below are MeSH descriptors whose meaning is more specific than "Receptor-Interacting Protein Serine-Threonine Kinases".
				
			 
		 
	 
 
                                        
                                            
	
	
		
			
			
					
				This graph shows the total number of publications written about "Receptor-Interacting Protein Serine-Threonine Kinases" by people in this website by year, and whether "Receptor-Interacting Protein Serine-Threonine Kinases" was a major or minor topic of these publications. 
				
					
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		            | Year | Major Topic | Minor Topic | Total | 
|---|
| 2006 | 0 | 1 | 1 | 
| 2009 | 0 | 1 | 1 | 
| 2012 | 1 | 0 | 1 | 
| 2014 | 1 | 0 | 1 | 
| 2015 | 1 | 0 | 1 | 
| 2016 | 0 | 1 | 1 | 
| 2018 | 1 | 0 | 1 | 
| 2021 | 1 | 0 | 1 | 
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				Below are the most recent publications written about "Receptor-Interacting Protein Serine-Threonine Kinases" by people in Profiles.
						
					
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RIP3-dependent necroptosis contributes to the pathogenesis of chronic obstructive pulmonary disease. JCI Insight. 2021 06 22; 6(12).
															
								 
							
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Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA-dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis. J Biol Chem. 2019 01 11; 294(2):502-519.
															
								 
							
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Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control. Oncotarget. 2016 Oct 25; 7(43):69371-69383.
															
								 
							
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RIP1 and RIP3 complex regulates radiation-induced programmed necrosis in glioblastoma. Tumour Biol. 2016 Jun; 37(6):7525-34.
															
								 
							
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Receptor-interacting protein kinases modulate noise-induced sensory hair cell death. Cell Death Dis. 2014 May 29; 5:e1262.
															
								 
							
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Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. EMBO Mol Med. 2013 01; 5(1):105-21.
															
								 
							
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Nitration of the mitochondrial complex I subunit NDUFB8 elicits RIP1- and RIP3-mediated necrosis. Free Radic Biol Med. 2010 Jan 15; 48(2):306-17.
															
								 
							
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DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas. J Cell Mol Med. 2010 Jun; 14(6A):1303-17.
															
								 
							
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Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis-inducing ligand induced apoptotic and nonapoptotic signals in non small cell lung carcinoma cells. Cancer Res. 2007 Jul 15; 67(14):6946-55.
															
								 
							
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ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. J Immunol. 2006 Apr 15; 176(8):4979-86.