Von Hippel-Lindau Tumor Suppressor Protein
"Von Hippel-Lindau Tumor Suppressor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME.
| Descriptor ID |
D051794
|
| MeSH Number(s) |
D08.811.464.938.750.875 D12.776.624.776.865
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Von Hippel-Lindau Tumor Suppressor Protein".
Below are MeSH descriptors whose meaning is more specific than "Von Hippel-Lindau Tumor Suppressor Protein".
This graph shows the total number of publications written about "Von Hippel-Lindau Tumor Suppressor Protein" by people in this website by year, and whether "Von Hippel-Lindau Tumor Suppressor Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 2 | 1 | 3 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Von Hippel-Lindau Tumor Suppressor Protein" by people in Profiles.
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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Nat Commun. 2021 11 25; 12(1):6896.
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CD3Z hypermethylation is associated with severe clinical manifestations in systemic lupus erythematosus and reduces CD3?-chain expression in T cells. Rheumatology (Oxford). 2017 03 01; 56(3):467-476.
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pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner. Science. 2016 08 26; 353(6302):929-32.
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A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma. FASEB J. 2015 Jul; 29(7):2803-13.
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Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma. BMC Cancer. 2010 Nov 09; 10:619.
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The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma. Mol Cancer. 2009 Jul 30; 8:52.
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Hypoxia-inducible factor-2alpha regulates the expression of TRAIL receptor DR5 in renal cancer cells. Carcinogenesis. 2008 Sep; 29(9):1734-41.
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Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells. Carcinogenesis. 2008 Apr; 29(4):696-703.
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Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology. Adv Exp Med Biol. 2008; 605:51-6.
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A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma. Genes Chromosomes Cancer. 2007 Sep; 46(9):805-12.