Guanylate Cyclase

"Guanylate Cyclase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.

Descriptor ID	D006162
MeSH Number(s)	D08.811.520.650.600 D12.644.360.350 D12.776.476.350
Concept/Terms	Guanylate Cyclase Guanylate Cyclase Cyclase, Guanylate Guanyl Cyclase Cyclase, Guanyl Guanylyl Cyclase Cyclase, Guanylyl Inosinate Cyclase Cyclase, Inosinate Deoxyguanylate Cyclase Cyclase, Deoxyguanylate

Below are MeSH descriptors whose meaning is more general than "Guanylate Cyclase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Lyases [D08.811.520]
Phosphorus-Oxygen Lyases [D08.811.520.650]
Guanylate Cyclase [D08.811.520.650.600]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Guanylate Cyclase [D12.644.360.350]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Guanylate Cyclase [D12.776.476.350]

Below are MeSH descriptors whose meaning is related to "Guanylate Cyclase".

Below are MeSH descriptors whose meaning is more specific than "Guanylate Cyclase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Guanylate Cyclase" by people in this website by year, and whether "Guanylate Cyclase" was a major or minor topic of these publications.

Bar chart showing 18 publications over 13 distinct years, with a maximum of 2 publications in 2000 and 2006 and 2008 and 2011 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1996	1	0	1
1999	0	1	1
2000	1	1	2
2001	0	1	1
2005	1	0	1
2006	0	2	2
2007	0	1	1
2008	1	1	2
2011	1	1	2
2015	1	1	2
2018	1	0	1
2020	0	1	1

Below are the most recent publications written about "Guanylate Cyclase" by people in Profiles.

Udelson JE, Lewis GD, Shah SJ, Zile MR, Redfield MM, Burnett J, Parker J, Seferovic JP, Wilson P, Mittleman RS, Profy AT, Konstam MA. Effect of Praliciguat on Peak Rate of Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: The CAPACITY HFpEF Randomized Clinical Trial. JAMA. 2020 10 20; 324(15):1522-1531.

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Dasgupta S, Gomez JJ, Singh I, Khan M. S-Nitrosylation in Regulation of Inflammation and Cell Damage. Curr Drug Targets. 2018; 19(15):1831-1838.

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Goulopoulou S, Hannan JL, Matsumoto T, Ogbi S, Ergul A, Webb RC. Reduced vascular responses to soluble guanylyl cyclase but increased sensitivity to sildenafil in female rats with type 2 diabetes. Am J Physiol Heart Circ Physiol. 2015 Jul 15; 309(2):H297-304.

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Makowski CT, Rissmiller RW, Bullington WM. Riociguat: a novel new drug for treatment of pulmonary hypertension. Pharmacotherapy. 2015 May; 35(5):502-19.

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Tennyson AG, Lippard SJ. Generation, translocation, and action of nitric oxide in living systems. Chem Biol. 2011 Oct 28; 18(10):1211-20.

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Lettieri JT, Scheerans C, Blunck M, Mazzu AL, Frey R, Mück W, Sundaresan PR. Assessment of the effects of renal impairment on the pharmacokinetics of the soluble guanylate cyclase activator cinaciguat after a single intravenous dose. J Clin Pharmacol. 2012 Aug; 52(8):1240-7.

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Zhang H, Fan J, Li S, Karan S, Rohrer B, Palczewski K, Frederick JM, Crouch RK, Baehr W. Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci. 2008 Apr 09; 28(15):4008-14.

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D'Angelis CA, Holm BA, Lakshminrusimha S, Nickerson PA, Swartz DD, Sokolowski J, Nielsen LC, Ryan RM. Ontogeny of atrial natriuretic peptide and its receptor in the lung: effects on perinatal surfactant release. Pediatr Res. 2008 Mar; 63(3):239-44.

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Ying L, Hofseth AB, Browning DD, Nagarkatti M, Nagarkatti PS, Hofseth LJ. Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation. Cancer Res. 2007 Oct 01; 67(19):9286-93.

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Estevez ME, Ala-Laurila P, Crouch RK, Cornwall MC. Turning cones off: the role of the 9-methyl group of retinal in red cones. J Gen Physiol. 2006 Dec; 128(6):671-85.

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