"Alkylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.
| Descriptor ID |
D000478
|
| MeSH Number(s) |
G02.111.035 G02.607.094 G03.059
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Alkylation".
Below are MeSH descriptors whose meaning is more specific than "Alkylation".
This graph shows the total number of publications written about "Alkylation" by people in this website by year, and whether "Alkylation" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Alkylation" by people in Profiles.
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5,5-Dialkylluciferins are thermal stable substrates for bioluminescence-based detection systems. PLoS One. 2020; 15(12):e0243747.
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Studies at the ionizable position of cephalosporins and penicillins: hydroxamates as substitutes for the traditional carboxylate group. J Antibiot (Tokyo). 2017 Mar; 70(3):292-296.
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Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites. Bioorg Med Chem. 2015 Aug 15; 23(16):5131-43.
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Texas 3-step decellularization protocol: looking at the cardiac extracellular matrix. J Proteomics. 2013 Jun 28; 86:43-52.
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Reductive N-alkylation of nitroarenes: a green approach for the N-alkylation of natural products. J Org Chem. 2012 May 18; 77(10):4578-85.
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Natural product DNA major groove binders. Nat Prod Rep. 2012 Feb; 29(2):134-43.
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Fluoroalkylation of imidazoles by hypervalent iodonium salts. Org Lett. 2008 Dec 18; 10(24):5565-8.
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Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia. Mol Cancer Ther. 2008 Apr; 7(4):769-78.
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Construction of N-1H,1H-perfluoroalkylated peptide bonds. Chem Commun (Camb). 2008 Jan 14; (2):208-10.
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Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates. Nucleic Acids Res. 2007; 35(1):307-16.