"Bcl-2-Like Protein 11" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A BCL-2-like protein that has a C-terminal BCL-2 homology (BH3) domain and forms heterodimers with other BCL-2 FAMILY PROTEINS. It is a strong inducer of APOPTOSIS and ANOIKIS; several isoforms are expressed (BimEL, Bim L, Bim-alpha, Bim-s; and Bim-gamma) that have different potencies for inducing apoptosis.
| Descriptor ID |
D000072224
|
| MeSH Number(s) |
D12.644.360.075.323 D12.776.476.075.323 D12.776.543.116 D12.776.624.664.700.025
|
| Concept/Terms |
Bcl-2-Like Protein 11- Bcl-2-Like Protein 11
- 11, Bcl-2-Like Protein
- Bcl 2 Like Protein 11
- Protein 11, Bcl-2-Like
- Bcl-2-Interacting Mediator of Cell Death
- Bcl 2 Interacting Mediator of Cell Death
- Bcl-2-Binding Protein, BIM
- BIM Bcl-2-Binding Protein
- Bcl 2 Binding Protein, BIM
- Protein, BIM Bcl-2-Binding
- BCL2L11 Protein
- Protein, BCL2L11
- BIM Protein
- Protein, BIM
|
Below are MeSH descriptors whose meaning is more general than "Bcl-2-Like Protein 11".
Below are MeSH descriptors whose meaning is more specific than "Bcl-2-Like Protein 11".
This graph shows the total number of publications written about "Bcl-2-Like Protein 11" by people in this website by year, and whether "Bcl-2-Like Protein 11" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Bcl-2-Like Protein 11" by people in Profiles.
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Upregulation of the EGFR/MEK1/MAPK1/2 signaling axis as a mechanism of resistance to antiestrogen-induced BimEL dependent apoptosis in ER+ breast cancer cells. Int J Oncol. 2023 Feb; 62(2).
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Bcl-2-enhanced efficacy of microtubule-targeting chemotherapy through Bim overexpression: implications for cancer treatment. Neoplasia. 2013 Jan; 15(1):49-60.
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Kallistatin attenuates endothelial apoptosis through inhibition of oxidative stress and activation of Akt-eNOS signaling. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1419-27.
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Runx1 is a co-activator with FOXO3 to mediate transforming growth factor beta (TGFbeta)-induced Bim transcription in hepatic cells. J Biol Chem. 2009 Jul 24; 284(30):20227-39.
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Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise & fall of Bim. Cell Cycle. 2009 Jan 01; 8(1):11-7.
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TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2. EMBO Rep. 2008 Oct; 9(10):990-7.
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Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function. J Biol Chem. 2006 Jan 13; 281(2):813-23.
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The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. Mol Cancer Ther. 2005 Mar; 4(3):443-9.
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Smad3 potentiates transforming growth factor beta (TGFbeta )-induced apoptosis and expression of the BH3-only protein Bim in WEHI 231 B lymphocytes. J Biol Chem. 2003 May 16; 278(20):18069-77.