Calcineurin

"Calcineurin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.

Descriptor ID	D019703
MeSH Number(s)	D08.811.277.352.650.625.150 D12.644.360.087 D12.776.476.087
Concept/Terms	Calcineurin Calcineurin Protein Phosphatase 3 Phosphatase 3, Protein Protein Phosphatase-2B Protein Phosphatase 2B Calcineurin B Calcineurin B Protein Phosphatase 3 Regulatory Subunit Calcineurin A Calcineurin A Protein Phosphatase 3 Catalytic Subunit

Below are MeSH descriptors whose meaning is more general than "Calcineurin".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Monoester Hydrolases [D08.811.277.352.650]
Phosphoprotein Phosphatases [D08.811.277.352.650.625]
Calcineurin [D08.811.277.352.650.625.150]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Calcineurin [D12.644.360.087]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Calcineurin [D12.776.476.087]

Below are MeSH descriptors whose meaning is related to "Calcineurin".

Below are MeSH descriptors whose meaning is more specific than "Calcineurin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Calcineurin" by people in this website by year, and whether "Calcineurin" was a major or minor topic of these publications.

Bar chart showing 10 publications over 10 distinct years, with a maximum of 1 publications in 1999 and 2001 and 2002 and 2003 and 2004 and 2005 and 2006 and 2008 and 2011 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2001	1	0	1
2002	0	1	1
2003	0	1	1
2004	0	1	1
2005	0	1	1
2006	0	1	1
2008	0	1	1
2011	1	0	1
2020	1	0	1

Below are the most recent publications written about "Calcineurin" by people in Profiles.

Pan B, Li J, Parajuli N, Tian Z, Wu P, Lewno MT, Zou J, Wang W, Bedford L, Mayer RJ, Fang J, Liu J, Cui T, Su H, Wang X. The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction. Circ Res. 2020 07 31; 127(4):502-518.

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Yamaguchi N, Chakraborty A, Pasek DA, Molkentin JD, Meissner G. Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. Am J Physiol Heart Circ Physiol. 2011 Jun; 300(6):H2187-95.

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Gupta S, Manicassamy S, Vasu C, Kumar A, Shang W, Sun Z. Differential requirement of PKC-theta in the development and function of natural regulatory T cells. Mol Immunol. 2008 Dec; 46(2):213-24.

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Flavell SW, Cowan CW, Kim TK, Greer PL, Lin Y, Paradis S, Griffith EC, Hu LS, Chen C, Greenberg ME. Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science. 2006 Feb 17; 311(5763):1008-12.

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Lang H, Schulte BA, Schmiedt RA. Ouabain induces apoptotic cell death in type I spiral ganglion neurons, but not type II neurons. J Assoc Res Otolaryngol. 2005 Mar; 6(1):63-74.

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Lebeche D, Kaprielian R, del Monte F, Tomaselli G, Gwathmey JK, Schwartz A, Hajjar RJ. In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis. Circulation. 2004 Nov 30; 110(22):3435-43.

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Waldmeier PC, Zimmermann K, Qian T, Tintelnot-Blomley M, Lemasters JJ. Cyclophilin D as a drug target. Curr Med Chem. 2003 Aug; 10(16):1485-506.

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Evens AM, Kwaan HC, Kaufman DB, Bennett CL. TTP/HUS occurring in a simultaneous pancreas/kidney transplant recipient after clopidogrel treatment: evidence of a nonimmunological etiology. Transplantation. 2002 Sep 27; 74(6):885-7.

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Haq S, Choukroun G, Lim H, Tymitz KM, del Monte F, Gwathmey J, Grazette L, Michael A, Hajjar R, Force T, Molkentin JD. Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure. Circulation. 2001 Feb 06; 103(5):670-7.

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Ding B, Price RL, Borg TK, Weinberg EO, Halloran PF, Lorell BH. Pressure overload induces severe hypertrophy in mice treated with cyclosporine, an inhibitor of calcineurin. Circ Res. 1999 Apr 02; 84(6):729-34.

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