Structure-Activity Relationship
"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
| Descriptor ID |
D013329
|
| MeSH Number(s) |
G02.111.830 G07.690.773.997
|
| Concept/Terms |
Structure-Activity Relationship- Structure-Activity Relationship
- Relationship, Structure-Activity
- Relationships, Structure-Activity
- Structure Activity Relationship
- Structure-Activity Relationships
|
Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".
This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 3 | 3 |
| 1995 | 0 | 10 | 10 |
| 1996 | 0 | 13 | 13 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 10 | 10 |
| 1999 | 0 | 5 | 5 |
| 2000 | 0 | 6 | 6 |
| 2001 | 0 | 7 | 7 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 11 | 11 |
| 2004 | 0 | 16 | 16 |
| 2005 | 0 | 12 | 12 |
| 2006 | 0 | 22 | 22 |
| 2007 | 0 | 11 | 11 |
| 2008 | 0 | 10 | 10 |
| 2009 | 0 | 15 | 15 |
| 2010 | 0 | 12 | 12 |
| 2011 | 0 | 12 | 12 |
| 2012 | 0 | 9 | 9 |
| 2013 | 0 | 20 | 20 |
| 2014 | 0 | 10 | 10 |
| 2015 | 1 | 15 | 16 |
| 2016 | 0 | 14 | 14 |
| 2017 | 0 | 10 | 10 |
| 2018 | 0 | 4 | 4 |
| 2019 | 0 | 9 | 9 |
| 2020 | 0 | 7 | 7 |
| 2021 | 0 | 8 | 8 |
| 2022 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.
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A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics. J Med Chem. 2022 02 24; 65(4):3420-3433.
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Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1. J Med Chem. 2021 12 23; 64(24):17753-17776.
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Structure-activity and mechanistic studies of non-peptidic inhibitors of the PLK1 polo box domain identified through REPLACE. Eur J Med Chem. 2022 Jan 05; 227:113926.
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Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-? (ROR?) Agonist for Use in Treating Cancer. J Med Chem. 2021 09 23; 64(18):13410-13428.
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Nonpeptidic, Polo-Box Domain-Targeted Inhibitors of PLK1 Block Kinase Activity, Induce Its Degradation and Target-Resistant Cells. J Med Chem. 2021 07 22; 64(14):9916-9925.
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Structural basis for plazomicin antibiotic action and resistance. Commun Biol. 2021 06 11; 4(1):729.
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Sec24C is an HIV-1 host dependency factor crucial for virus replication. Nat Microbiol. 2021 04; 6(4):435-444.
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Evaluation of NanoLuc substrates for bioluminescence imaging of transferred cells in mice. J Photochem Photobiol B. 2021 Mar; 216:112128.
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Synthesis of erythro- B13 enantiomers and stereospecific action of full set of B13-isomers in MCF7 breast carcinoma cells: Cellular metabolism and effects on sphingolipids. Bioorg Med Chem. 2021 02 15; 32:116011.
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BION-2: Predicting Positions of Non-Specifically Bound Ions on Protein Surface by a Gaussian-Based Treatment of Electrostatics. Int J Mol Sci. 2020 Dec 29; 22(1).