"MutL Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that forms MutL homodimers or heterodimers between MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.
Below are MeSH descriptors whose meaning is more general than "MutL Proteins".
Below are MeSH descriptors whose meaning is more specific than "MutL Proteins".
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Below are the most recent publications written about "MutL Proteins" by people in Profiles.
Defects of DNA mismatch repair in human prostate cancer. Cancer Res. 2001 May 15; 61(10):4112-21.