"Elongin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heterotrimeric protein complex composed of 110 kDa elongin A, 18 kDa elongin B, and 15 kDa elongin C subunits. It functions as a positive regulator of RNA POLYMERASE II, increasing its rate of transcriptional elongation by suppressing transient pausing along the DNA template. Elongin A is the transcriptionally active component; elongins B and C enhance its activity.
| Descriptor ID |
D000075065
|
| MeSH Number(s) |
D12.776.260.197 D12.776.930.215
|
| Concept/Terms |
Elongin- Elongin
- SIII Elongation Factor
- Elongation Factor, SIII
- TF-SIII
- Transcription Factor SIII
- SIII, Transcription Factor
- Elongin Complex
- Complex, Elongin
|
Below are MeSH descriptors whose meaning is more general than "Elongin".
Below are MeSH descriptors whose meaning is more specific than "Elongin".
This graph shows the total number of publications written about "Elongin" by people in this website by year, and whether "Elongin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Elongin" by people in Profiles.
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Conformational Dynamics of the HIV-Vif Protein Complex. Biophys J. 2019 04 23; 116(8):1432-1445.
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CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. EMBO J. 2018 09 14; 37(18).