Nucleic Acid Denaturation

"Nucleic Acid Denaturation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.

Descriptor ID	D009691
MeSH Number(s)	E05.393.640 G02.111.603 G05.627
Concept/Terms	Nucleic Acid Denaturation Nucleic Acid Denaturation Acid Denaturation, Nucleic Denaturation, Nucleic Acid Nucleic Acid Denaturations RNA Denaturation RNA Denaturation Denaturation, RNA DNA Denaturation DNA Denaturation Denaturation, DNA DNA Melting

Below are MeSH descriptors whose meaning is more general than "Nucleic Acid Denaturation".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Nucleic Acid Denaturation [E05.393.640]
Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Nucleic Acid Denaturation [G02.111.603]
Genetic Phenomena [G05]
Nucleic Acid Denaturation [G05.627]

Below are MeSH descriptors whose meaning is related to "Nucleic Acid Denaturation".

Below are MeSH descriptors whose meaning is more specific than "Nucleic Acid Denaturation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Nucleic Acid Denaturation" by people in this website by year, and whether "Nucleic Acid Denaturation" was a major or minor topic of these publications.

Bar chart showing 13 publications over 10 distinct years, with a maximum of 2 publications in 2005 and 2010 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
2000	0	1	1
2005	1	1	2
2007	0	1	1
2008	0	1	1
2009	0	1	1
2010	0	2	2
2011	0	2	2
2012	0	1	1
2013	0	1	1

Below are the most recent publications written about "Nucleic Acid Denaturation" by people in Profiles.

Ranjan N, Davis E, Xue L, Arya DP. Dual recognition of the human telomeric G-quadruplex by a neomycin-anthraquinone conjugate. Chem Commun (Camb). 2013 Jun 28; 49(51):5796-8.

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Charles I, Davis E, Arya DP. Efficient stabilization of phosphodiester (PO), phosphorothioate (PS), and 2'-O-methoxy (2'-OMe) DNA·RNA hybrid duplexes by amino sugars. Biochemistry. 2012 Jul 10; 51(27):5496-505.

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Hentosh P, Benjamin T, Hall L, Leap S, Loescher J, Poyner E, Sundin T, Whittle M, Wilkinson S, Peffley DM. Xeroderma pigmentosum variant: complementary molecular approaches to detect a 13 base pair deletion in the DNA polymerase eta gene. Exp Mol Pathol. 2011 Oct; 91(2):528-33.

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Xue L, Ranjan N, Arya DP. Synthesis and spectroscopic studies of the aminoglycoside (neomycin)--perylene conjugate binding to human telomeric DNA. Biochemistry. 2011 Apr 12; 50(14):2838-49.

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Arya DP. New approaches toward recognition of nucleic acid triple helices. Acc Chem Res. 2011 Feb 15; 44(2):134-46.

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Xue L, Xi H, Kumar S, Gray D, Davis E, Hamilton P, Skriba M, Arya DP. Probing the recognition surface of a DNA triplex: binding studies with intercalator-neomycin conjugates. Biochemistry. 2010 Jul 06; 49(26):5540-52.

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Kaplan DL, Bastia D. Mechanisms of polar arrest of a replication fork. Mol Microbiol. 2009 Apr; 72(2):279-85.

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Bastia D, Zzaman S, Krings G, Saxena M, Peng X, Greenberg MM. Replication termination mechanism as revealed by Tus-mediated polar arrest of a sliding helicase. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12831-6.

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Dobrowolski SF, Ellingson C, Coyne T, Grey J, Martin R, Naylor EW, Koch R, Levy HL. Mutations in the phenylalanine hydroxylase gene identified in 95 patients with phenylketonuria using novel systems of mutation scanning and specific genotyping based upon thermal melt profiles. Mol Genet Metab. 2007 Jul; 91(3):218-27.

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Zzaman S, Bastia D. Oligomeric initiator protein-mediated DNA looping negatively regulates plasmid replication in vitro by preventing origin melting. Mol Cell. 2005 Dec 22; 20(6):833-43.

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