"Syk Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An SH2 domain-containing non-receptor tyrosine kinase that regulates signal transduction downstream of a variety of receptors including B-CELL ANTIGEN RECEPTORS. It functions in both INNATE IMMUNITY and ADAPTIVE IMMUNITY and also mediates signaling in CELL ADHESION; OSTEOGENESIS; PLATELET ACTIVATION; and vascular development.
| Descriptor ID |
D000072377
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.650 D12.644.360.900 D12.776.476.913
|
| Concept/Terms |
Syk Kinase- Syk Kinase
- Kinase, Syk
- SYK Tyrosine Kinase
- Kinase, SYK Tyrosine
- Tyrosine Kinase, SYK
- Spleen Tyrosine Kinase
- Kinase, Spleen Tyrosine
- Tyrosine Kinase, Spleen
|
Below are MeSH descriptors whose meaning is more general than "Syk Kinase".
Below are MeSH descriptors whose meaning is more specific than "Syk Kinase".
This graph shows the total number of publications written about "Syk Kinase" by people in this website by year, and whether "Syk Kinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2002 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2019 | 0 | 2 | 2 |
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Below are the most recent publications written about "Syk Kinase" by people in Profiles.
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Basophil histamine release in patients with chronic spontaneous urticaria: Optimize or minimize. J Allergy Clin Immunol. 2019 08; 144(2):622-623.
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Lactic acid suppresses IgE-mediated mast cell function in vitro and in vivo. Cell Immunol. 2019 07; 341:103918.
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Osteoclast inhibitory peptide-1 binding to the Fc gammaRIIB inhibits osteoclast differentiation. Endocrinology. 2010 Sep; 151(9):4389-99.
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Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity. 2006 Aug; 25(2):271-83.
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The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. Mol Cell Biol. 2002 Apr; 22(8):2524-35.
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Protein tyrosine phosphorylation in T cell signaling. Front Biosci. 2002 Apr 01; 7:d918-69.
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Induction of autoimmunity in a transgenic model of B cell receptor peripheral tolerance: changes in coreceptors and B cell receptor-induced tyrosine-phosphoproteins. J Immunol. 1999 Nov 15; 163(10):5287-97.
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The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase. J Immunol. 1999 Aug 15; 163(4):1894-905.
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Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase. J Biol Chem. 1996 Mar 15; 271(11):6458-66.