PTEN Phosphohydrolase

"PTEN Phosphohydrolase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.

Descriptor ID	D051059
MeSH Number(s)	D08.811.277.352.650.850 D12.776.476.590 D12.776.624.776.695
Concept/Terms	PTEN Phosphohydrolase PTEN Phosphohydrolase Phosphohydrolase, PTEN PTEN Protein Phosphatase and Tensin Homologue on Chromosome Ten Protein PTEN Phosphatase Phosphatase, PTEN MMAC1 Protein PTEN Protein Phosphatase Phosphatase, PTEN Protein Protein Phosphatase, PTEN Mutated In Multiple Advanced Cancers 1 Protein

Below are MeSH descriptors whose meaning is more general than "PTEN Phosphohydrolase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Monoester Hydrolases [D08.811.277.352.650]
PTEN Phosphohydrolase [D08.811.277.352.650.850]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
PTEN Phosphohydrolase [D12.776.476.590]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
PTEN Phosphohydrolase [D12.776.624.776.695]

Below are MeSH descriptors whose meaning is related to "PTEN Phosphohydrolase".

Below are MeSH descriptors whose meaning is more specific than "PTEN Phosphohydrolase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "PTEN Phosphohydrolase" by people in this website by year, and whether "PTEN Phosphohydrolase" was a major or minor topic of these publications.

Bar chart showing 58 publications over 21 distinct years, with a maximum of 5 publications in 2007 and 2011 and 2015 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2001	0	2	2
2002	0	2	2
2004	0	2	2
2006	1	0	1
2007	3	2	5
2008	2	1	3
2009	4	0	4
2010	3	1	4
2011	3	2	5
2012	0	1	1
2013	1	1	2
2014	1	1	2
2015	3	2	5
2016	2	0	2
2017	1	2	3
2018	3	2	5
2019	2	1	3
2020	1	1	2
2021	1	1	2
2022	1	1	2

Below are the most recent publications written about "PTEN Phosphohydrolase" by people in Profiles.

Lefler JE, Seward C, Ostrowski MC. PTEN in cancer associated fibroblasts. Adv Cancer Res. 2022; 154:203-226.

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Yoshida A, Phillips-Mason P, Tarallo V, Avril S, Koivisto C, Leone G, Diehl JA. Non-phosphorylatable cyclin D1 mutant potentiates endometrial hyperplasia and drives carcinoma with Pten loss. Oncogene. 2022 04; 41(15):2187-2195.

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Liu S, Knochelmann HM, Lomeli SH, Hong A, Richardson M, Yang Z, Lim RJ, Wang Y, Dumitras C, Krysan K, Timmers C, Romeo MJ, Krieg C, O'Quinn EC, Horton JD, Dubinett SM, Paulos CM, Neskey DM, Lo RS. Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma. Cell Rep Med. 2021 10 19; 2(10):100411.

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Jones CE, Sharick JT, Colbert SE, Shukla VC, Zent JM, Ostrowski MC, Ghadiali SN, Sizemore ST, Leight JL. Pten regulates collagen fibrillogenesis by fibroblasts through SPARC. PLoS One. 2021; 16(2):e0245653.

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Koivisto CS, Parrish M, Bonala SB, Ngoi S, Torres A, Gallagher J, Sanchez-Hodge R, Zeinner V, Nahhas GJ, Liu B, Cohn DE, Backes FJ, Goodfellow PJ, Chamberlin HM, Leone G. Evaluating the efficacy of enzalutamide and the development of resistance in a preclinical mouse model of type-I endometrial carcinoma. Neoplasia. 2020 10; 22(10):484-496.

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Dimou A, Nasarre C, Peterson YK, Pagano R, Gooz M, Nasarre P, Drabkin HA, Armeson KE, Gibney BC, Gemmill RM, Denlinger CE. Neuropilin-2b facilitates resistance to tyrosine kinase inhibitors in non-small cell lung cancer. J Thorac Cardiovasc Surg. 2021 08; 162(2):463-473.

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Thies KA, Lefler JE, Leone G, Ostrowski MC. PTEN in the Stroma. Cold Spring Harb Perspect Med. 2019 10 01; 9(10).

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Chandrasekaran S, Sasaki M, Scharer CD, Kissick HT, Patterson DG, Magliocca KR, Seykora JT, Sapkota B, Gutman DA, Cooper LA, Lesinski GB, Waller EK, Thomas SN, Kotenko SV, Boss JM, Moreno CS, Swerlick RA, Pollack BP. Phosphoinositide 3-Kinase Signaling Can Modulate MHC Class I and II Expression. Mol Cancer Res. 2019 12; 17(12):2395-2409.

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Zhang J, Lee YR, Dang F, Gan W, Menon AV, Katon JM, Hsu CH, Asara JM, Tibarewal P, Leslie NR, Shi Y, Pandolfi PP, Wei W. PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. Cancer Discov. 2019 09; 9(9):1306-1323.

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Jones CE, Hammer AM, Cho Y, Sizemore GM, Cukierman E, Yee LD, Ghadiali SN, Ostrowski MC, Leight JL. Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland. Neoplasia. 2019 01; 21(1):132-145.

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