"Substrate Specificity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
| Descriptor ID |
D013379
|
| MeSH Number(s) |
G02.111.835
|
| Concept/Terms |
Substrate Specificity- Substrate Specificity
- Specificities, Substrate
- Specificity, Substrate
- Substrate Specificities
|
Below are MeSH descriptors whose meaning is more general than "Substrate Specificity".
Below are MeSH descriptors whose meaning is more specific than "Substrate Specificity".
This graph shows the total number of publications written about "Substrate Specificity" by people in this website by year, and whether "Substrate Specificity" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 7 | 7 |
| 1995 | 0 | 4 | 4 |
| 1996 | 0 | 8 | 8 |
| 1997 | 0 | 6 | 6 |
| 1998 | 0 | 5 | 5 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 5 | 5 |
| 2001 | 0 | 4 | 4 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 15 | 15 |
| 2004 | 0 | 8 | 8 |
| 2005 | 1 | 5 | 6 |
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 9 | 9 |
| 2008 | 0 | 9 | 9 |
| 2009 | 0 | 8 | 8 |
| 2010 | 0 | 16 | 16 |
| 2011 | 0 | 8 | 8 |
| 2012 | 0 | 4 | 4 |
| 2013 | 0 | 4 | 4 |
| 2014 | 0 | 3 | 3 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 5 | 5 |
| 2017 | 0 | 7 | 7 |
| 2018 | 0 | 2 | 2 |
| 2019 | 0 | 4 | 4 |
| 2020 | 0 | 4 | 4 |
| 2021 | 0 | 4 | 4 |
| 2022 | 0 | 2 | 2 |
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click here.
Below are the most recent publications written about "Substrate Specificity" by people in Profiles.
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Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes. Nat Commun. 2022 03 28; 13(1):1647.
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A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics. J Med Chem. 2022 02 24; 65(4):3420-3433.
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A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease. Cell Rep. 2021 09 28; 36(13):109754.
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Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2') enzymes. Sci Rep. 2021 06 02; 11(1):11614.
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Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation. Nat Chem Biol. 2021 05; 17(5):615-623.
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Optimization of Multiple Glycosidase and Chemical Stabilization Strategies for N-Glycan Isomer Detection by Mass Spectrometry Imaging in Formalin-Fixed, Paraffin-Embedded Tissues. Methods Mol Biol. 2021; 2271:303-316.
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5,5-Dialkylluciferins are thermal stable substrates for bioluminescence-based detection systems. PLoS One. 2020; 15(12):e0243747.
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Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design. Sci Adv. 2020 10; 6(42).
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Evaluating Brightness and Spectral Properties of Click Beetle and Firefly Luciferases Using Luciferin Analogues: Identification of Preferred Pairings of Luciferase and Substrate for In Vivo Bioluminescence Imaging. Mol Imaging Biol. 2020 12; 22(6):1523-1531.
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Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals. Nat Methods. 2020 08; 17(8):852-860.