I-kappa B Kinase

"I-kappa B Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.

Descriptor ID	D051550
MeSH Number(s)	D08.811.913.696.620.682.700.494 D12.644.360.361 D12.776.476.378
Concept/Terms	I-kappa B Kinase I-kappa B Kinase B Kinase, I-kappa Kinase, I-kappa B NK-kappa B-Activating Kinase NAK NK kappa B Activating Kinase NAK IkappaB Kinase Kinase, IkappaB I kappa B Kinase IkappaB Kinase gamma IkappaB Kinase gamma IKK gamma NF-kappaB Essential Modifier Essential Modifier, NF-kappaB NF kappaB Essential Modifier IkappaB Kinase epsilon IkappaB Kinase epsilon Kinase epsilon, IkappaB IKK epsilon IKKepsilon IkappaB Kinase alpha IkappaB Kinase alpha Kinase alpha, IkappaB IKK 1 Kinase IKK alpha Conserved Helix-Loop-Helix Ubiquitous Kinase Conserved Helix Loop Helix Ubiquitous Kinase CHUK Kinase I Kappa B alpha-Associated Protein Kinase I Kappa B alpha Associated Protein Kinase IkappaBalpha Kinase IkappaB Kinase beta IkappaB Kinase beta Kinase beta, IkappaB IKK beta IKBKB IKK 2 Kinase

Below are MeSH descriptors whose meaning is more general than "I-kappa B Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
I-kappa B Kinase [D08.811.913.696.620.682.700.494]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
I-kappa B Kinase [D12.644.360.361]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
I-kappa B Kinase [D12.776.476.378]

Below are MeSH descriptors whose meaning is related to "I-kappa B Kinase".

Below are MeSH descriptors whose meaning is more specific than "I-kappa B Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "I-kappa B Kinase" by people in this website by year, and whether "I-kappa B Kinase" was a major or minor topic of these publications.

Bar chart showing 34 publications over 18 distinct years, with a maximum of 4 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2001	0	1	1
2002	0	2	2
2003	0	1	1
2004	0	1	1
2005	0	1	1
2006	0	2	2
2007	1	2	3
2008	2	2	4
2009	0	2	2
2010	1	0	1
2011	2	1	3
2012	3	0	3
2013	1	2	3
2015	0	2	2
2016	1	1	2
2017	0	1	1
2018	0	1	1

Below are the most recent publications written about "I-kappa B Kinase" by people in Profiles.

Chen S, Bonifati S, Qin Z, St Gelais C, Kodigepalli KM, Barrett BS, Kim SH, Antonucci JM, Ladner KJ, Buzovetsky O, Knecht KM, Xiong Y, Yount JS, Guttridge DC, Santiago ML, Wu L. SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-?B and interferon pathways. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3798-E3807.

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Cleary MM, Mansoor A, Settelmeyer T, Ijiri Y, Ladner KJ, Svalina MN, Rubin BP, Guttridge DC, Keller C. NF?B signaling in alveolar rhabdomyosarcoma. Dis Model Mech. 2017 09 01; 10(9):1109-1115.

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Maharry SE, Walker CJ, Liyanarachchi S, Mehta S, Patel M, Bainazar MA, Huang X, Lankenau MA, Hoag KW, Ranganathan P, Garzon R, Blachly JS, Guttridge DC, Bloomfield CD, de la Chapelle A, Eisfeld AK. Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia. Cancer Discov. 2016 09; 6(9):1036-51.

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Jones JT, Qian X, van der Velden JL, Chia SB, McMillan DH, Flemer S, Hoffman SM, Lahue KG, Schneider RW, Nolin JD, Anathy V, van der Vliet A, Townsend DM, Tew KD, Janssen-Heininger YM. Glutathione S-transferase pi modulates NF-?B activation and pro-inflammatory responses in lung epithelial cells. Redox Biol. 2016 08; 8:375-82.

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Duckworth C, Zhang L, Carroll SL, Ethier SP, Cheung HW. Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression. Oncogene. 2016 08 04; 35(31):4036-47.

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Klein T, Fung SY, Renner F, Blank MA, Dufour A, Kang S, Bolger-Munro M, Scurll JM, Priatel JJ, Schweigler P, Melkko S, Gold MR, Viner RI, Régnier CH, Turvey SE, Overall CM. The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-?B signalling. Nat Commun. 2015 Nov 03; 6:8777.

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Adada MM, Orr-Gandy KA, Snider AJ, Canals D, Hannun YA, Obeid LM, Clarke CJ. Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor ?B activation. J Biol Chem. 2013 Sep 20; 288(38):27667-27679.

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Ying Z, do Carmo JM, Xiang L, da Silva AA, Chen M, Ryan MJ, Ostrowski M, Rajagopalan S, Hall JE. Inhibitor ?B kinase 2 is a myosin light chain kinase in vascular smooth muscle. Circ Res. 2013 Aug 16; 113(5):562-70.

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Shintaku J, Guttridge DC. Reining in nuclear factor-kappaB in skeletal muscle disorders. Curr Opin Clin Nutr Metab Care. 2013 May; 16(3):251-7.

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Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M. Chronic epithelial NF-?B activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14007-12.

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