Heat Shock Transcription Factors
"Heat Shock Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Heat and cold stress-inducible, transcription factors that bind to inverted 5'-NGAAN-3' pentamer DNA sequences and are regulated by poly(ADP) ribosylation. They play essential roles as transcriptional activators of the HEAT-SHOCK RESPONSE by inducing expression of large classes of MOLECULAR CHAPERONES and heat-shock proteins. They also function in DNA REPAIR; transcriptional reactivation of latent HIV-1; and pre-mRNA processing and nuclear export of HSP70 HEAT-SHOCK PROTEINS during heat stress.
| Descriptor ID |
D000076249
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| MeSH Number(s) |
D12.776.157.687.450 D12.776.260.260 D12.776.660.720.462 D12.776.930.317
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Heat Shock Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "Heat Shock Transcription Factors".
This graph shows the total number of publications written about "Heat Shock Transcription Factors" by people in this website by year, and whether "Heat Shock Transcription Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Heat Shock Transcription Factors" by people in Profiles.
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Heat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis. J Biol Chem. 2012 Oct 12; 287(42):35646-35657.
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Hsp70 inhibits aminoglycoside-induced hair cell death and is necessary for the protective effect of heat shock. J Assoc Res Otolaryngol. 2008 Sep; 9(3):277-89.
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The retinoid antagonist MX781 induces clusterin expression in prostate cancer cells via heat shock factor-1 and activator protein-1 transcription factors. Cancer Res. 2004 Aug 15; 64(16):5905-12.
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Functional role for heat shock factors in the transcriptional regulation of human RANK ligand gene expression in stromal/osteoblast cells. J Biol Chem. 2004 Mar 12; 279(11):10500-7.