Protein Phosphatase 2

"Protein Phosphatase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.

Descriptor ID	D054648
MeSH Number(s)	D08.811.277.352.650.625.706 D12.644.360.583 D12.776.476.561
Concept/Terms	Protein Phosphatase 2 Protein Phosphatase 2 Protein Phosphatase-2A Protein Phosphatase 2A Protein Phosphatase 2, Catalytic Subunit, alpha Isoform Protein Phosphatase 2, Catalytic Subunit, alpha Isoform PPP2CA Phosphatase Phosphatase, PPP2CA Protein Phosphatase 2A, Catalytic Subunit, alpha Isoform Serine-Threonine-Protein Phosphatase 2A Catalytic Subunit alpha Isoform Serine Threonine Protein Phosphatase 2A Catalytic Subunit alpha Isoform Protein Phosphatase 2, Catalytic Subunit, beta Isoform Protein Phosphatase 2, Catalytic Subunit, beta Isoform Protein Phosphatase 2A, Catalytic Subunit, beta Isoform PPP2CB Phosphatase Phosphatase, PPP2CB Serine Threonine Protein Phosphatase 2A Catalytic Subunit beta Isoform Protein Phosphatase 2, Regulatory Subunit Protein Phosphatase 2, Regulatory Subunit Protein Phosphatase 2, Regulatory Subunit A, alpha Isoform Protein Phosphatase 2, Regulatory Subunit A, alpha Isoform Protein Phosphatase 2A, Regulatory Subunit A , alpha Isoform Protein Phosphatase 2, Regulatory Subunit B, alpha Isoform Protein Phosphatase 2, Regulatory Subunit B, alpha Isoform Protein Phosphatase 2A, Regulatory Subunit B, alpha Isoform Protein Phosphatase 2, Regulatory Subunit B, beta Isoform Protein Phosphatase 2, Regulatory Subunit B, beta Isoform Protein Phosphatase 2A, Regulatory Subunit B, beta Isoform Protein Phosphatase 2, Regulatory Subunit B, delta Isoform Protein Phosphatase 2, Regulatory Subunit B, delta Isoform Protein Phosphatase 2A, Regulatory Subunit B, delta Isoform Protein Phosphatase 2, Regulatory Subunit B, gamma Isoform Protein Phosphatase 2, Regulatory Subunit B, gamma Isoform Protein Phosphatase 2A, Regulatory Subunit B, gamma Isoform Protein Phosphatase 2, Catalytic Subunit Protein Phosphatase 2, Catalytic Subunit Protein Phosphatase 2, Regulatory Subunit A, beta Isoform Protein Phosphatase 2, Regulatory Subunit A, beta Isoform Protein Phosphatase 2A, Regulatory Subunit A, beta Isoform

Below are MeSH descriptors whose meaning is more general than "Protein Phosphatase 2".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Monoester Hydrolases [D08.811.277.352.650]
Phosphoprotein Phosphatases [D08.811.277.352.650.625]
Protein Phosphatase 2 [D08.811.277.352.650.625.706]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Protein Phosphatase 2 [D12.644.360.583]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Protein Phosphatase 2 [D12.776.476.561]

Below are MeSH descriptors whose meaning is related to "Protein Phosphatase 2".

Below are MeSH descriptors whose meaning is more specific than "Protein Phosphatase 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Phosphatase 2" by people in this website by year, and whether "Protein Phosphatase 2" was a major or minor topic of these publications.

Bar chart showing 36 publications over 19 distinct years, with a maximum of 4 publications in 2011 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	0	2	2
1998	0	1	1
1999	0	2	2
2001	0	1	1
2002	0	1	1
2004	0	1	1
2005	0	3	3
2008	1	1	2
2009	0	1	1
2010	1	1	2
2011	2	2	4
2012	1	2	3
2013	2	2	4
2014	1	0	1
2017	1	1	2
2018	1	1	2
2019	2	0	2
2020	1	0	1
2021	1	0	1

Below are the most recent publications written about "Protein Phosphatase 2" by people in Profiles.

Chu H, Sacharidou A, Nguyen A, Li C, Chambliss KL, Salmon JE, Shen YM, Lo J, Leone GW, Herz J, Hui DY, Marciano DK, Abrahams VM, Natale BV, Montalbano AP, Xiao X, Xu L, Natale DR, Shaul PW, Mineo C. Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome. Circ Res. 2021 09 17; 129(7):735-750.

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Matmati N, Hassan BH, Ren J, Shamssedine AA, Jeong E, Shariff B, Snider J, Rødkær SV, Chen G, Mohanty BK, Zheng WJ, Obeid LM, Røssel-Larsen M, Færgeman NJ, Hannun YA. Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by a CDC55-Dependent Mechanism. Mol Cell Biol. 2020 05 28; 40(12).

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Albadrani M, Seth RK, Sarkar S, Kimono D, Mondal A, Bose D, Porter DE, Scott GI, Brooks B, Raychoudhury S, Nagarkatti M, Nagarkatti P, Jule Y, Diehl AM, Chatterjee S. Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21. Am J Physiol Gastrointest Liver Physiol. 2019 10 01; 317(4):G408-G428.

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De Palma RM, Parnham SR, Li Y, Oaks JJ, Peterson YK, Szulc ZM, Roth BM, Xing Y, Ogretmen B. The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction. FASEB J. 2019 06; 33(6):7647-7666.

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Hsu AH, Lum MA, Shim KS, Frederick PJ, Morrison CD, Chen B, Lele SM, Sheinin YM, Daikoku T, Dey SK, Leone G, Black AR, Black JD. Crosstalk between PKCa and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium. Cell Rep. 2018 07 17; 24(3):655-669.

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Rizvi F, Siddiqui R, DeFranco A, Homar P, Emelyanova L, Holmuhamedov E, Ross G, Tajik AJ, Jahangir A. Simvastatin reduces TGF-ß1-induced SMAD2/3-dependent human ventricular fibroblasts differentiation: Role of protein phosphatase activation. Int J Cardiol. 2018 Nov 01; 270:228-236.

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Vilaça R, Barros I, Matmati N, Silva E, Martins T, Teixeira V, Hannun YA, Costa V. The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1. Biochim Biophys Acta Mol Basis Dis. 2018 Jan; 1864(1):79-88.

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Wende AR, Kim J, Holland WL, Wayment BE, O'Neill BT, Tuinei J, Brahma MK, Pepin ME, McCrory MA, Luptak I, Halade GV, Litwin SE, Abel ED. Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses. Am J Physiol Heart Circ Physiol. 2017 Dec 01; 313(6):H1098-H1108.

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Nagpal K, Watanabe KS, Tsao BP, Tsokos GC. Transcription factor Ikaros represses protein phosphatase 2A (PP2A) expression through an intronic binding site. J Biol Chem. 2014 May 16; 289(20):13751-7.

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Neviani P, Harb JG, Oaks JJ, Santhanam R, Walker CJ, Ellis JJ, Ferenchak G, Dorrance AM, Paisie CA, Eiring AM, Ma Y, Mao HC, Zhang B, Wunderlich M, May PC, Sun C, Saddoughi SA, Bielawski J, Blum W, Klisovic RB, Solt JA, Byrd JC, Volinia S, Cortes J, Huettner CS, Koschmieder S, Holyoake TL, Devine S, Caligiuri MA, Croce CM, Garzon R, Ogretmen B, Arlinghaus RB, Chen CS, Bittman R, Hokland P, Roy DC, Milojkovic D, Apperley J, Goldman JM, Reid A, Mulloy JC, Bhatia R, Marcucci G, Perrotti D. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. J Clin Invest. 2013 Oct; 123(10):4144-57.

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