Interleukin-1 Receptor-Associated Kinases

"Interleukin-1 Receptor-Associated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of intracellular signaling kinases that were identified by their ability to signal from the activated INTERLEUKIN-1 RECEPTORS. Signaling from these kinases involves their interaction with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88 and TNF RECEPTOR-ASSOCIATED FACTOR 6.

Descriptor ID	D053592
MeSH Number(s)	D08.811.913.696.620.682.700.526 D12.644.360.370 D12.776.476.384
Concept/Terms	Interleukin-1 Receptor-Associated Kinases Interleukin-1 Receptor-Associated Kinases Interleukin 1 Receptor Associated Kinases Kinases, Interleukin-1 Receptor-Associated Receptor-Associated Kinases, Interleukin-1 IRAK Kinases Kinases, IRAK IL-1 Receptor-Associated Kinase IL 1 Receptor Associated Kinase Kinase, IL-1 Receptor-Associated Receptor-Associated Kinase, IL-1 Interleukin-1 Receptor-Associated Kinase Interleukin 1 Receptor Associated Kinase Kinase, Interleukin-1 Receptor-Associated Receptor-Associated Kinase, Interleukin-1 Interleukin-1 Receptor-Associated Kinase 4 Interleukin-1 Receptor-Associated Kinase 4 Interleukin 1 Receptor Associated Kinase 4 IRAK-4 Kinase IRAK 4 Kinase Kinase, IRAK-4 Interleukin-1 Receptor-Associated Kinase 3 Interleukin-1 Receptor-Associated Kinase 3 Interleukin 1 Receptor Associated Kinase 3 IRAK-3 Kinase IRAK 3 Kinase Kinase, IRAK-3 Interleukin-1 Receptor-Associated Kinase 1 Interleukin-1 Receptor-Associated Kinase 1 Interleukin 1 Receptor Associated Kinase 1 IRAK-1 Kinase IRAK 1 Kinase Kinase, IRAK-1 Interleukin-1 Receptor-Associated Kinase 2 Interleukin-1 Receptor-Associated Kinase 2 Interleukin 1 Receptor Associated Kinase 2 IRAK-2 Kinase IRAK 2 Kinase Kinase, IRAK-2

Below are MeSH descriptors whose meaning is more general than "Interleukin-1 Receptor-Associated Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Interleukin-1 Receptor-Associated Kinases [D08.811.913.696.620.682.700.526]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Interleukin-1 Receptor-Associated Kinases [D12.644.360.370]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Interleukin-1 Receptor-Associated Kinases [D12.776.476.384]

Below are MeSH descriptors whose meaning is related to "Interleukin-1 Receptor-Associated Kinases".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-1 Receptor-Associated Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-1 Receptor-Associated Kinases" by people in this website by year, and whether "Interleukin-1 Receptor-Associated Kinases" was a major or minor topic of these publications.

Bar chart showing 7 publications over 6 distinct years, with a maximum of 2 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2009	1	0	1
2012	1	0	1
2013	0	1	1
2015	0	2	2
2016	0	1	1

Below are the most recent publications written about "Interleukin-1 Receptor-Associated Kinases" by people in Profiles.

Alarcón-Riquelme ME, Ziegler JT, Molineros J, Howard TD, Moreno-Estrada A, Sánchez-Rodríguez E, Ainsworth HC, Ortiz-Tello P, Comeau ME, Rasmussen A, Kelly JA, Adler A, Acevedo-Vázquez EM, Cucho-Venegas JM, García-De la Torre I, Cardiel MH, Miranda P, Catoggio LJ, Maradiaga-Ceceña M, Gaffney PM, Vyse TJ, Criswell LA, Tsao BP, Sivils KL, Bae SC, James JA, Kimberly RP, Kaufman KM, Harley JB, Esquivel-Valerio JA, Moctezuma JF, García MA, Berbotto GA, Babini AM, Scherbarth H, Toloza S, Baca V, Nath SK, Aguilar Salinas C, Orozco L, Tusié-Luna T, Zidovetzki R, Pons-Estel BA, Langefeld CD, Jacob CO. Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture. Arthritis Rheumatol. 2016 Apr; 68(4):932-43.

View in: PubMed
Tomar S, Nagarkatti M, Nagarkatti PS. 3,3'-Diindolylmethane attenuates LPS-mediated acute liver failure by regulating miRNAs to target IRAK4 and suppress Toll-like receptor signalling. Br J Pharmacol. 2015 Apr; 172(8):2133-47.

View in: PubMed
Tomar S, Zumbrun EE, Nagarkatti M, Nagarkatti PS. Protective role of cannabinoid receptor 2 activation in galactosamine/lipopolysaccharide-induced acute liver failure through regulation of macrophage polarization and microRNAs. J Pharmacol Exp Ther. 2015 May; 353(2):369-79.

View in: PubMed
Jin J, Zhang X, Lu Z, Perry DM, Li Y, Russo SB, Cowart LA, Hannun YA, Huang Y. Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages. Am J Physiol Endocrinol Metab. 2013 Oct 01; 305(7):E853-67.

View in: PubMed
Kaufman KM, Zhao J, Kelly JA, Hughes T, Adler A, Sanchez E, Ojwang JO, Langefeld CD, Ziegler JT, Williams AH, Comeau ME, Marion MC, Glenn SB, Cantor RM, Grossman JM, Hahn BH, Song YW, Yu CY, James JA, Guthridge JM, Brown EE, Alarcón GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri MA, Reveille JD, Vilá LM, Anaya JM, Boackle SA, Stevens AM, Freedman BI, Criswell LA, Pons Estel BA, Lee JH, Lee JS, Chang DM, Scofield RH, Gilkeson GS, Merrill JT, Niewold TB, Vyse TJ, Bae SC, Alarcón-Riquelme ME, Jacob CO, Moser Sivils K, Gaffney PM, Harley JB, Sawalha AH, Tsao BP. Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Ann Rheum Dis. 2013 Mar; 72(3):437-44.

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Jacob CO, Zhu J, Armstrong DL, Yan M, Han J, Zhou XJ, Thomas JA, Reiff A, Myones BL, Ojwang JO, Kaufman KM, Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Silverman E, Ziegler J, Kelly JA, Merrill JT, Harley JB, Ramsey-Goldman R, Vila LM, Bae SC, Vyse TJ, Gilkeson GS, Gaffney PM, Moser KL, Langefeld CD, Zidovetzki R, Mohan C. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6256-61.

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Ferlito M, Romanenko OG, Ashton S, Squadrito F, Halushka PV, Cook JA. Effect of cross-tolerance between endotoxin and TNF-alpha or IL-1beta on cellular signaling and mediator production. J Leukoc Biol. 2001 Nov; 70(5):821-9.

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