"rho-Associated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
| Descriptor ID |
D054460
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.814 D12.644.360.590 D12.776.476.595
|
| Concept/Terms |
rho-Associated Kinases- rho-Associated Kinases
- rho Associated Kinases
- rho-Associated Kinase
- rho Associated Kinase
- ROCK Protein Kinases
- Protein Kinases, ROCK
- rho-Associated Coiled-Coil Kinase
- Coiled-Coil Kinase, rho-Associated
- rho Associated Coiled Coil Kinase
- rho-Kinase
- rho Kinase
- ROK Kinase
rho-Associated Kinase 1- rho-Associated Kinase 1
- rho Associated Kinase 1
- ROCK-I Protein Kinase
- ROCK I Protein Kinase
- p160ROCK
- rho-Associated Kinase beta
- rho Associated Kinase beta
- rho-Associated Protein Kinase beta
- rho Associated Protein Kinase beta
- rho-Associated Coiled-Coil Containing Protein Kinase 1
- rho Associated Coiled Coil Containing Protein Kinase 1
rho-Associated Kinase 2- rho-Associated Kinase 2
- rho Associated Kinase 2
- rho-Associated Kinase alpha
- rho Associated Kinase alpha
- rho-Associated Coiled-Coil Containing Protein Kinase 2
- rho Associated Coiled Coil Containing Protein Kinase 2
- ROCK-II Protein Kinase
- ROCK II Protein Kinase
- p160 rhoA-Binding Kinase ROKalpha
- p160 rhoA Binding Kinase ROKalpha
- rho-Associated Protein Kinase alpha
- rho Associated Protein Kinase alpha
|
Below are MeSH descriptors whose meaning is more general than "rho-Associated Kinases".
Below are MeSH descriptors whose meaning is more specific than "rho-Associated Kinases".
This graph shows the total number of publications written about "rho-Associated Kinases" by people in this website by year, and whether "rho-Associated Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 2 | 0 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 2 | 1 | 3 |
| 2015 | 1 | 1 | 2 |
| 2018 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "rho-Associated Kinases" by people in Profiles.
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R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells. Cell Commun Signal. 2021 09 16; 19(1):95.
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RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation. J Cell Sci. 2018 05 15; 131(10).
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Combination therapy of lovastatin and AMP-activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model. Immunology. 2018 07; 154(3):434-451.
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The Role of Thrombin and Cell Contractility in Regulating Clustering and Collective Migration of Corneal Fibroblasts in Different ECM Environments. Invest Ophthalmol Vis Sci. 2015 Mar 03; 56(3):2079-90.
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Noise-induced cochlear F-actin depolymerization is mediated via ROCK2/p-ERM signaling. J Neurochem. 2015 Jun; 133(5):617-28.
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The Rho guanine nucleotide exchange factor Syx regulates the balance of dia and ROCK activities to promote polarized-cancer-cell migration. Mol Cell Biol. 2013 Dec; 33(24):4909-18.
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Modulation of Rho-Rock signaling pathway protects oligodendrocytes against cytokine toxicity via PPAR-a-dependent mechanism. Glia. 2013 Sep; 61(9):1500-1517.
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The role of RhoA and cytoskeleton in myofibroblast transformation in hyperoxic lung fibrosis. Free Radic Biol Med. 2013 Aug; 61:26-39.
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Fluid flow forces and rhoA regulate fibrous development of the atrioventricular valves. Dev Biol. 2013 Feb 15; 374(2):345-56.
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Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis. Am J Pathol. 2012 Sep; 181(3):993-1006.