NF-kappa B

"NF-kappa B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

Descriptor ID	D016328
MeSH Number(s)	D12.776.260.600 D12.776.660.600 D12.776.930.600
Concept/Terms	NF-kappa B NF-kappa B kappa B Enhancer Binding Protein NF-kappaB NF kappaB Transcription Factor NF-kB Factor NF-kB, Transcription NF-kB, Transcription Factor Transcription Factor NF kB NF-kB NF kB Immunoglobulin Enhancer-Binding Protein Enhancer-Binding Protein, Immunoglobulin Immunoglobulin Enhancer Binding Protein Nuclear Factor kappa B Ig-EBP-1 Ig-EBP-1 Ig EBP 1

Below are MeSH descriptors whose meaning is more general than "NF-kappa B".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
NF-kappa B [D12.776.260.600]
Nuclear Proteins [D12.776.660]
NF-kappa B [D12.776.660.600]
Transcription Factors [D12.776.930]
NF-kappa B [D12.776.930.600]

Below are MeSH descriptors whose meaning is related to "NF-kappa B".

Below are MeSH descriptors whose meaning is more specific than "NF-kappa B".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NF-kappa B" by people in this website by year, and whether "NF-kappa B" was a major or minor topic of these publications.

Bar chart showing 302 publications over 29 distinct years, with a maximum of 22 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	0	1
1995	0	1	1
1996	0	1	1
1997	2	4	6
1998	1	5	6
1999	4	4	8
2000	7	4	11
2001	5	5	10
2002	4	8	12
2003	3	10	13
2004	12	10	22
2005	4	10	14
2006	6	7	13
2007	10	10	20
2008	6	6	12
2009	3	8	11
2010	7	10	17
2011	6	10	16
2012	7	10	17
2013	7	10	17
2014	3	8	11
2015	3	11	14
2016	6	8	14
2017	6	6	12
2018	5	3	8
2019	2	4	6
2020	1	5	6
2021	2	0	2
2022	0	1	1

Below are the most recent publications written about "NF-kappa B" by people in Profiles.

Cook M, Lin H, Mishra SK, Wang GY. BAY 11-7082 inhibits the secretion of interleukin-6 by senescent human microglia. Biochem Biophys Res Commun. 2022 08 20; 617(Pt 1):30-35.

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Fung SY, Lu HY, Sharma M, Sharma AA, Saferali A, Jia A, Abraham L, Klein T, Gold MR, Noterangelo LD, Overall CM, Turvey SE. MALT1-Dependent Cleavage of HOIL1 Modulates Canonical NF-?B Signaling and Inflammatory Responsiveness. Front Immunol. 2021; 12:749794.

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Sajan MP, Leitges M, Park C, Diamond DM, Wu J, Hansen BC, Duncan MA, Apostolatos CA, Apostolatos AH, Kindy M, Farese RV. Control of ß-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-?/? and Nuclear Factor ?-B. Curr Alzheimer Res. 2021; 18(12):941-955.

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Tateishi K, Miyake Y, Kawazu M, Sasaki N, Nakamura T, Sasame J, Yoshii Y, Ueno T, Miyake A, Watanabe J, Matsushita Y, Shiba N, Udaka N, Ohki K, Fink AL, Tummala SS, Natsumeda M, Ikegaya N, Nishi M, Ohtake M, Miyazaki R, Suenaga J, Murata H, Aoki I, Miller JJ, Fujii Y, Ryo A, Yamanaka S, Mano H, Cahill DP, Wakimoto H, Chi AS, Batchelor TT, Nagane M, Ichimura K, Yamamoto T. A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma. Cancer Res. 2020 12 01; 80(23):5330-5343.

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Eastman AJ, Vrana EN, Grimaldo MT, Jones AD, Rogers LM, Alcendor DJ, Aronoff DM. Cytotrophoblasts suppress macrophage-mediated inflammation through a contact-dependent mechanism. Am J Reprod Immunol. 2021 03; 85(3):e13352.

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Wu Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Zingarelli B, Fan H. miR-145a Regulation of Pericyte Dysfunction in a Murine Model of Sepsis. J Infect Dis. 2020 08 17; 222(6):1037-1045.

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Lim JT, Singh N, Leuvano LA, Calvert VS, Petricoin EF, Teachey DT, Lock RB, Padi M, Kraft AS, Padi SKR. PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis. Mol Cancer Ther. 2020 09; 19(9):1809-1821.

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Mondal A, Bose D, Saha P, Sarkar S, Seth R, Kimono D, Albadrani M, Nagarkatti M, Nagarkatti P, Chatterjee S. Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis. J Neuroinflammation. 2020 Jul 04; 17(1):201.

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Huang X, Li Y, Li X, Fan D, Xin HB, Fu M. TRIM14 promotes endothelial activation via activating NF-?B signaling pathway. J Mol Cell Biol. 2020 04 24; 12(3):176-189.

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Larit F, León F, Benyahia S, Cutler SJ. Total Phenolic and Flavonoid Content and Biological Activities of Extracts and Isolated Compounds of Cytisus villosus Pourr. Biomolecules. 2019 11 13; 9(11).

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