TOR Serine-Threonine Kinases

"TOR Serine-Threonine Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of RAPAMYCIN due to the discovery that SIROLIMUS (commonly known as rapamycin) forms an inhibitory complex with TACROLIMUS BINDING PROTEIN 1A that blocks the action of its enzymatic activity.

Descriptor ID	D058570
MeSH Number(s)	D08.811.913.696.620.682.700.931 D12.776.476.925
Concept/Terms	TOR Serine-Threonine Kinases TOR Serine-Threonine Kinases Kinases, TOR Serine-Threonine Serine-Threonine Kinases, TOR TOR Serine Threonine Kinases Target of Rapamycin Proteins Rapamycin Proteins Target mTOR Serine-Threonine Kinases Kinases, mTOR Serine-Threonine Serine-Threonine Kinases, mTOR mTOR Serine Threonine Kinases Mechanistic Target of Rapamycin Protein FK506 Binding Protein 12-Rapamycin Associated Protein 1 FK506 Binding Protein 12 Rapamycin Associated Protein 1 TOR Kinases FKBP12-Rapamycin Associated Protein Associated Protein, FKBP12-Rapamycin FKBP12 Rapamycin Associated Protein Protein, FKBP12-Rapamycin Associated FKBP12-Rapamycin Complex-Associated Protein Complex-Associated Protein, FKBP12-Rapamycin FKBP12 Rapamycin Complex Associated Protein Protein, FKBP12-Rapamycin Complex-Associated RAFT-1 Protein Protein, RAFT-1 RAFT 1 Protein Rapamycin Target Protein Protein, Rapamycin Target Target Protein, Rapamycin mTOR Protein Protein, mTOR

Below are MeSH descriptors whose meaning is more general than "TOR Serine-Threonine Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
TOR Serine-Threonine Kinases [D08.811.913.696.620.682.700.931]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
TOR Serine-Threonine Kinases [D12.776.476.925]

Below are MeSH descriptors whose meaning is related to "TOR Serine-Threonine Kinases".

Below are MeSH descriptors whose meaning is more specific than "TOR Serine-Threonine Kinases".

TOR Serine-Threonine Kinases
Mechanistic Target of Rapamycin Complex 1
Mechanistic Target of Rapamycin Complex 2

publications

Timeline | Most Recent

This graph shows the total number of publications written about "TOR Serine-Threonine Kinases" by people in this website by year, and whether "TOR Serine-Threonine Kinases" was a major or minor topic of these publications.

Bar chart showing 76 publications over 18 distinct years, with a maximum of 14 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2005	0	1	1
2007	0	3	3
2008	0	4	4
2009	0	4	4
2010	0	2	2
2011	0	2	2
2012	3	5	8
2013	8	6	14
2014	4	3	7
2015	2	4	6
2016	3	1	4
2017	3	1	4
2018	2	2	4
2019	0	5	5
2020	2	1	3
2021	3	0	3
2022	1	0	1

Below are the most recent publications written about "TOR Serine-Threonine Kinases" by people in Profiles.

Liu L, Dai X, Yin S, Liu P, Hill EG, Wei W, Gan W. DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway. Sci Signal. 2022 01 04; 15(715):eabh2290.

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Peng Y, Liou B, Lin Y, Fannin V, Zhang W, Feldman RA, Setchell KDR, Grabowski GA, Sun Y. Substrate Reduction Therapy Reverses Mitochondrial, mTOR, and Autophagy Alterations in a Cell Model of Gaucher Disease. Cells. 2021 09 02; 10(9).

View in: PubMed
Yin S, Liu L, Gan W. The Roles of Post-Translational Modifications on mTOR Signaling. Int J Mol Sci. 2021 Feb 11; 22(4).

View in: PubMed
Ge Z, Song C, Ding Y, Tan BH, Desai D, Sharma A, Gowda R, Yue F, Huang S, Spiegelman V, Payne JL, Reeves ME, Iyer S, Dhanyamraju PK, Imamura Y, Bogush D, Bamme Y, Yang Y, Soliman M, Kane S, Dovat E, Schramm J, Hu T, McGrath M, Chroneos ZC, Payne KJ, Gowda C, Dovat S. Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia. Leukemia. 2021 05; 35(5):1267-1278.

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Lim JT, Singh N, Leuvano LA, Calvert VS, Petricoin EF, Teachey DT, Lock RB, Padi M, Kraft AS, Padi SKR. PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis. Mol Cancer Ther. 2020 09; 19(9):1809-1821.

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Hammad SM, Twal WO, Arif E, Semler AJ, Klein RL, Nihalani D. Transcriptomics Reveal Altered Metabolic and Signaling Pathways in Podocytes Exposed to C16 Ceramide-Enriched Lipoproteins. Genes (Basel). 2020 02 07; 11(2).

View in: PubMed
Zhang X, Sergin I, Evans TD, Jeong SJ, Rodriguez-Velez A, Kapoor D, Chen S, Song E, Holloway KB, Crowley JR, Epelman S, Weihl CC, Diwan A, Fan D, Mittendorfer B, Stitziel NO, Schilling JD, Lodhi IJ, Razani B. High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy. Nat Metab. 2020 01; 2(1):110-125.

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Das A, Alshareef M, Henderson F, Martinez Santos JL, Vandergrift WA, Lindhorst SM, Varma AK, Infinger L, Patel SJ, Cachia D. Ganoderic acid A/DM-induced NDRG2 over-expression suppresses high-grade meningioma growth. Clin Transl Oncol. 2020 Jul; 22(7):1138-1145.

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Gutkind JS, Day TA, Lippman SM, Szabo E. Targeting mTOR in Head and Neck Cancer-Response. Clin Cancer Res. 2019 11 01; 25(21):6555.

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Salama MF, Liu M, Clarke CJ, Espaillat MP, Haley JD, Jin T, Wang D, Obeid LM, Hannun YA. PKCa is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation. Oncogene. 2019 11; 38(48):7311-7328.

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