MAP Kinase Kinase Kinases

"MAP Kinase Kinase Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).

Descriptor ID	D020930
MeSH Number(s)	D08.811.913.696.620.682.700.559 D12.644.360.400 D12.776.476.400
Concept/Terms	MAP Kinase Kinase Kinases MAP Kinase Kinase Kinases Mitogen-Activated Protein Kinase Kinase Kinases Mitogen Activated Protein Kinase Kinase Kinases Kinases, MAP Kinase Kinase MAP3 Kinases Kinases, MAP3 MAP Kinase Kinase Kinase MAPKKKs MAPK-ERK Kinase Kinases MAPK-ERK Kinase Kinases Kinase Kinases, MAPK-ERK Kinases, MAPK-ERK Kinase MAPK ERK Kinase Kinases MEK Kinases Kinases, MEK MEKKs

Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
MAP Kinase Kinase Kinases [D08.811.913.696.620.682.700.559]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
MAP Kinase Kinase Kinases [D12.644.360.400]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
MAP Kinase Kinase Kinases [D12.776.476.400]

Below are MeSH descriptors whose meaning is related to "MAP Kinase Kinase Kinases".

Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "MAP Kinase Kinase Kinases" by people in this website by year, and whether "MAP Kinase Kinase Kinases" was a major or minor topic of these publications.

Bar chart showing 26 publications over 18 distinct years, with a maximum of 4 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2000	2	0	2
2001	1	0	1
2002	0	1	1
2003	1	1	2
2004	0	1	1
2005	1	0	1
2007	1	3	4
2008	0	1	1
2009	1	0	1
2010	0	1	1
2012	0	1	1
2013	1	0	1
2014	1	0	1
2016	2	0	2
2017	0	1	1
2018	0	1	1
2019	2	1	3

Below are the most recent publications written about "MAP Kinase Kinase Kinases" by people in Profiles.

Hunter A, Dai Y, Brown KJ, Muise-Helmericks RC, Foley AC. TAK1/Map3k7 enhances differentiation of cardiogenic endoderm from mouse embryonic stem cells. J Mol Cell Cardiol. 2019 12; 137:132-142.

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Owen DH, Konda B, Sipos J, Liu T, Webb A, Ringel MD, Timmers CD, Shah MH. KRAS G12V Mutation in Acquired Resistance to Combined BRAF and MEK Inhibition in Papillary Thyroid Cancer. J Natl Compr Canc Netw. 2019 05 01; 17(5):409-413.

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Beneker CM, Rovoli M, Kontopidis G, Röring M, Galda S, Braun S, Brummer T, McInnes C. Design and Synthesis of Type-IV Inhibitors of BRAF Kinase That Block Dimerization and Overcome Paradoxical MEK/ERK Activation. J Med Chem. 2019 04 25; 62(8):3886-3897.

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Sarhan J, Liu BC, Muendlein HI, Li P, Nilson R, Tang AY, Rongvaux A, Bunnell SC, Shao F, Green DR, Poltorak A. Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection. Proc Natl Acad Sci U S A. 2018 11 13; 115(46):E10888-E10897.

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Ratnam NM, Peterson JM, Talbert EE, Ladner KJ, Rajasekera PV, Schmidt CR, Dillhoff ME, Swanson BJ, Haverick E, Kladney RD, Williams TM, Leone GW, Wang DJ, Guttridge DC. NF-?B regulates GDF-15 to suppress macrophage surveillance during early tumor development. J Clin Invest. 2017 Oct 02; 127(10):3796-3809.

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Kaufman JM, Yamada T, Park K, Timmers CD, Amann JM, Carbone DP. A Transcriptional Signature Identifies LKB1 Functional Status as a Novel Determinant of MEK Sensitivity in Lung Adenocarcinoma. Cancer Res. 2017 01 01; 77(1):153-163.

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Kim SH, Ezhilarasan R, Phillips E, Gallego-Perez D, Sparks A, Taylor D, Ladner K, Furuta T, Sabit H, Chhipa R, Cho JH, Mohyeldin A, Beck S, Kurozumi K, Kuroiwa T, Iwata R, Asai A, Kim J, Sulman EP, Cheng SY, Lee LJ, Nakada M, Guttridge D, DasGupta B, Goidts V, Bhat KP, Nakano I. Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-?B-dependent Manner. Cancer Cell. 2016 Feb 08; 29(2):201-13.

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Hochster HS, Uboha N, Messersmith W, Gold PJ, ONeil BH, Cohen D, Denlinger C, Cohen S, Leichman CG, Leichman L, Lenz HJ. Phase II study of selumetinib (AZD6244, ARRY-142886) plus irinotecan as second-line therapy in patients with K-RAS mutated colorectal cancer. Cancer Chemother Pharmacol. 2015 Jan; 75(1):17-23.

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Hirschhorn J, Mohanty S, Bhat NR. The role of tumor progression locus 2 protein kinase in glial inflammatory response. J Neurochem. 2014 Mar; 128(6):919-26.

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Jia S, Gao X, Lee SH, Maira SM, Wu X, Stack EC, Signoretti S, Loda M, Zhao JJ, Roberts TM. Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention. Cancer Discov. 2013 Jan; 3(1):44-51.

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