John O'Bryan

Concepts (384)

Concepts are derived automatically from a person's publications.
Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.


Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Adaptor Proteins, Vesicular Transport
24
2017
62
5.360
Why?
ras Proteins
12
2021
102
5.310
Why?
Signal Transduction
31
2022
2689
2.350
Why?
Neoplasms
9
2021
1664
2.130
Why?
Antineoplastic Agents
5
2021
1070
2.040
Why?
Proto-Oncogene Proteins p21(ras)
5
2022
78
1.910
Why?
Endocytosis
13
2016
113
1.850
Why?
Mutation
11
2022
1213
1.720
Why?
Neuroblastoma
6
2021
109
1.350
Why?
Ubiquitin
6
2009
74
1.290
Why?
ErbB Receptors
7
2013
239
1.260
Why?
Pancreatic Neoplasms
2
2022
332
1.240
Why?
Molecular Targeted Therapy
3
2021
170
1.010
Why?
Animals
47
2022
20880
1.000
Why?
Protein Multimerization
4
2018
71
0.990
Why?
Proto-Oncogene Proteins c-cbl
3
2013
5
0.950
Why?
Biological Products
2
2022
78
0.920
Why?
Down Syndrome
4
2016
120
0.910
Why?
Cell Membrane
6
2020
524
0.890
Why?
Nucleotides
2
2022
29
0.870
Why?
Genes, ras
2
2022
46
0.860
Why?
Phosphatidylinositol 3-Kinases
3
2015
223
0.830
Why?
Mice
26
2022
8474
0.800
Why?
COS Cells
12
2021
155
0.790
Why?
Intracellular Signaling Peptides and Proteins
2
2013
216
0.790
Why?
Class II Phosphatidylinositol 3-Kinases
4
2015
4
0.770
Why?
Single-Domain Antibodies
1
2021
3
0.760
Why?
Antibodies, Monoclonal
3
2021
511
0.760
Why?
Allosteric Site
2
2020
17
0.760
Why?
Protein Engineering
1
2021
35
0.750
Why?
Carcinoma, Pancreatic Ductal
1
2021
46
0.750
Why?
Membrane Proteins
6
2022
617
0.710
Why?
Carcinogenesis
3
2022
124
0.690
Why?
Carrier Proteins
7
2011
597
0.680
Why?
Humans
50
2022
68549
0.650
Why?
Receptor Protein-Tyrosine Kinases
9
2013
100
0.650
Why?
Nerve Tissue Proteins
6
2007
290
0.640
Why?
Ubiquitination
4
2020
85
0.610
Why?
Protein Binding
12
2021
1027
0.600
Why?
Protein Tyrosine Phosphatase, Non-Receptor Type 11
2
2015
19
0.590
Why?
Multigene Family
3
2017
93
0.590
Why?
Proto-Oncogene Proteins c-akt
4
2018
331
0.590
Why?
Nuclear Proteins
3
2007
271
0.570
Why?
HEK293 Cells
7
2021
326
0.560
Why?
src Homology Domains
8
2015
29
0.550
Why?
Copper-transporting ATPases
3
2021
6
0.540
Why?
Transcription Factors
5
2011
753
0.540
Why?
Cytoskeletal Proteins
1
2016
108
0.540
Why?
Protein Kinase Inhibitors
1
2017
331
0.500
Why?
Vesicular Transport Proteins
3
2005
87
0.490
Why?
Adaptor Proteins, Signal Transducing
6
2011
214
0.490
Why?
Alzheimer Disease
3
2016
565
0.470
Why?
GTP Phosphohydrolases
5
2022
46
0.460
Why?
Cell Transformation, Neoplastic
3
2012
235
0.460
Why?
Phosphotyrosine
4
2000
41
0.450
Why?
Peptides
4
2015
455
0.440
Why?
DNA-Binding Proteins
4
2003
700
0.440
Why?
Mitogens
3
2001
45
0.430
Why?
Protein Interaction Maps
1
2012
30
0.410
Why?
Cell Line, Tumor
7
2022
1851
0.410
Why?
Gene Expression Regulation
2
2020
1293
0.400
Why?
Cell Line
10
2012
1752
0.400
Why?
Protein Interaction Mapping
1
2011
62
0.380
Why?
Green Fluorescent Proteins
1
2011
200
0.370
Why?
Neuropeptides
3
2002
106
0.370
Why?
Trans-Activators
1
2012
237
0.370
Why?
Microscopy, Fluorescence
1
2011
261
0.360
Why?
Allosteric Regulation
2
2020
58
0.360
Why?
Protein Transport
4
2018
280
0.350
Why?
Proteins
7
2004
473
0.350
Why?
Protein Isoforms
4
2016
246
0.340
Why?
JNK Mitogen-Activated Protein Kinases
2
2007
140
0.340
Why?
Oncogene Proteins
5
1999
35
0.340
Why?
Molecular Sequence Data
12
2015
1446
0.330
Why?
Reperfusion Injury
1
2012
320
0.330
Why?
Amino Acid Sequence
10
2015
1082
0.330
Why?
Superoxide Dismutase
2
2020
149
0.320
Why?
Ubiquitin-Protein Ligases
2
2009
89
0.320
Why?
Neurons
5
2021
881
0.320
Why?
Phosphorylation
12
2018
1200
0.320
Why?
Protein Processing, Post-Translational
3
2019
284
0.320
Why?
Motor Activity
1
2011
621
0.310
Why?
Neoplasm Transplantation
2
2020
160
0.310
Why?
Huntington Disease
1
2007
15
0.300
Why?
Enzyme Activation
5
2015
791
0.290
Why?
Protein Subunits
1
2007
99
0.290
Why?
Cells, Cultured
10
2021
2673
0.290
Why?
Structure-Activity Relationship
4
2017
420
0.290
Why?
Heart
1
2012
850
0.290
Why?
Two-Hybrid System Techniques
3
2012
28
0.280
Why?
Cell Proliferation
3
2022
1174
0.270
Why?
Caveolin 1
2
2020
59
0.270
Why?
Myocardium
1
2012
1204
0.260
Why?
Epidermal Growth Factor
3
2013
95
0.250
Why?
Brain
2
2011
2176
0.250
Why?
Mitogen-Activated Protein Kinases
2
2003
250
0.250
Why?
Recombinant Fusion Proteins
6
2007
376
0.250
Why?
High-Throughput Screening Assays
2
2017
48
0.250
Why?
HSP70 Heat-Shock Proteins
1
2005
42
0.250
Why?
Cell Survival
1
2007
901
0.240
Why?
MAP Kinase Kinase Kinase 1
1
2004
2
0.240
Why?
Cell Differentiation
6
2021
1034
0.240
Why?
Cardiomegaly
2
2015
213
0.230
Why?
Proto-Oncogene Proteins
9
2003
411
0.230
Why?
Leukemia
2
2022
117
0.230
Why?
Kidney
2
2005
945
0.220
Why?
MAP Kinase Signaling System
4
2022
247
0.220
Why?
Gene Silencing
2
2017
137
0.210
Why?
Mice, Knockout
6
2021
1692
0.210
Why?
Binding Sites
5
2005
631
0.210
Why?
Mice, Transgenic
3
2021
1033
0.200
Why?
Hematologic Neoplasms
1
2022
37
0.200
Why?
Protein-Tyrosine Kinases
3
2011
195
0.200
Why?
Base Sequence
7
2011
1015
0.200
Why?
Peptide Fragments
1
2004
483
0.200
Why?
P-type ATPases
1
2021
1
0.200
Why?
Clathrin
2
2000
17
0.200
Why?
Transcription, Genetic
1
2003
562
0.200
Why?
Vascular Endothelial Growth Factor Receptor-2
1
2021
32
0.190
Why?
Mutant Proteins
1
2021
45
0.190
Why?
Acetonitriles
1
2020
6
0.190
Why?
Metabolism
1
2020
12
0.190
Why?
Blood Vessels
1
2021
102
0.190
Why?
Endothelial Cells
2
2021
384
0.190
Why?
Dimerization
1
2020
99
0.190
Why?
Molecular Conformation
1
2020
128
0.180
Why?
Superoxide Dismutase-1
1
2020
41
0.180
Why?
3T3 Cells
7
2001
124
0.180
Why?
Catalytic Domain
1
2020
99
0.180
Why?
Xenograft Model Antitumor Assays
1
2021
304
0.180
Why?
Alternative Splicing
2
2019
93
0.180
Why?
Drug Design
1
2020
107
0.180
Why?
Oncogenes
1
2020
71
0.180
Why?
DNA Primers
3
2011
302
0.180
Why?
Graft vs Host Disease
1
2022
163
0.180
Why?
Hematopoietic Stem Cell Transplantation
1
2022
245
0.170
Why?
Protein Conformation
1
2020
362
0.170
Why?
Xenopus
3
2006
30
0.170
Why?
Pyrimidines
1
2020
178
0.170
Why?
Small Molecule Libraries
1
2019
53
0.170
Why?
Autophagy
1
2021
208
0.170
Why?
Piperazines
1
2020
206
0.170
Why?
Mice, Nude
2
2021
294
0.160
Why?
Mice, Inbred C57BL
5
2021
2791
0.160
Why?
Pyridines
1
2020
261
0.160
Why?
Drosophila
3
2007
37
0.160
Why?
Cyclic AMP-Dependent Protein Kinases
2
2015
93
0.150
Why?
Protein Structure, Secondary
1
2017
136
0.150
Why?
RNA Interference
3
2021
266
0.150
Why?
Transplantation, Heterologous
2
2021
122
0.150
Why?
Gene Expression
5
2012
770
0.150
Why?
Huntingtin Protein
2
2007
5
0.150
Why?
ets-Domain Protein Elk-1
3
2003
14
0.150
Why?
Oncogene Protein p21(ras)
1
2016
7
0.140
Why?
NIH 3T3 Cells
1
2016
65
0.140
Why?
Drug Discovery
1
2017
94
0.140
Why?
Lung Injury
1
2016
38
0.140
Why?
Diabetic Angiopathies
1
2018
203
0.140
Why?
Protein Kinases
1
2016
122
0.140
Why?
Muscle, Smooth, Vascular
1
2018
317
0.130
Why?
Endothelium, Vascular
1
2018
371
0.130
Why?
Models, Molecular
1
2017
546
0.130
Why?
Brain Chemistry
1
1996
173
0.130
Why?
Diabetes Mellitus, Experimental
1
2018
195
0.130
Why?
Proteasome Endopeptidase Complex
2
2020
69
0.130
Why?
Cyclic Nucleotide Phosphodiesterases, Type 4
1
2015
4
0.130
Why?
Recombinant Proteins
3
2011
742
0.130
Why?
Amino Acid Motifs
2
2007
77
0.120
Why?
Isoenzymes
2
2015
308
0.120
Why?
Gene Knockdown Techniques
1
2015
196
0.120
Why?
Genetic Predisposition to Disease
1
2017
786
0.120
Why?
Polymerase Chain Reaction
4
2004
492
0.120
Why?
Glioblastoma
1
2016
219
0.120
Why?
Gene Expression Regulation, Neoplastic
1
2017
756
0.110
Why?
Rats
6
2015
5300
0.110
Why?
Shc Signaling Adaptor Proteins
5
2004
26
0.110
Why?
Leukemia, Myeloid
2
1994
39
0.110
Why?
Brain Neoplasms
1
2016
371
0.110
Why?
Phosphatidylinositols
1
2012
40
0.100
Why?
Point Mutation
1
2012
97
0.100
Why?
Intellectual Disability
1
2013
114
0.100
Why?
Ventricular Myosins
1
2012
7
0.100
Why?
Cell Growth Processes
1
2012
40
0.100
Why?
Chromones
1
2012
33
0.100
Why?
Creatine Kinase
1
2012
46
0.100
Why?
Tetracycline
1
2012
29
0.100
Why?
Molecular Chaperones
2
2020
81
0.100
Why?
Myosin Heavy Chains
1
2012
49
0.100
Why?
Morpholines
1
2012
79
0.100
Why?
Protein Interaction Domains and Motifs
1
2011
57
0.100
Why?
Models, Biological
3
2006
981
0.100
Why?
Amino Acid Substitution
1
2011
137
0.100
Why?
Sequence Alignment
2
2007
165
0.100
Why?
Biolistics
1
2011
5
0.100
Why?
Mutagenesis, Site-Directed
1
2011
204
0.100
Why?
Onions
1
2011
4
0.100
Why?
Arabidopsis Proteins
1
2011
13
0.100
Why?
Myocytes, Cardiac
1
2015
442
0.100
Why?
Organ Size
1
2012
242
0.100
Why?
Disease Models, Animal
3
2017
2550
0.100
Why?
Arabidopsis
1
2011
20
0.100
Why?
Nervous System Diseases
1
2012
142
0.090
Why?
Disease
1
2010
41
0.090
Why?
Conserved Sequence
2
2004
67
0.090
Why?
In Vitro Techniques
1
2012
765
0.090
Why?
Proteolysis
2
2021
97
0.090
Why?
Receptors, Cell Surface
1
1991
248
0.090
Why?
Cognition Disorders
1
2013
342
0.090
Why?
Female
7
2021
38021
0.090
Why?
Promoter Regions, Genetic
1
2012
614
0.090
Why?
Neurons, Afferent
2
2000
32
0.090
Why?
Cloning, Molecular
5
2000
357
0.090
Why?
Mesenteric Arteries
2
2020
29
0.090
Why?
Blotting, Western
1
2011
954
0.080
Why?
Vasodilation
2
2020
85
0.080
Why?
Echocardiography
1
2012
515
0.080
Why?
Diabetes Mellitus, Type 2
1
2018
1085
0.080
Why?
Phenotype
1
2011
946
0.080
Why?
Src Homology 2 Domain-Containing, Transforming Protein 1
4
2004
15
0.080
Why?
Male
6
2021
37283
0.080
Why?
Epistasis, Genetic
1
2007
32
0.080
Why?
Cytoplasmic Vesicles
1
2006
3
0.070
Why?
Microscopy, Confocal
1
2007
337
0.070
Why?
Myocardial Infarction
1
2012
807
0.070
Why?
Immunoprecipitation
1
2006
132
0.070
Why?
HSC70 Heat-Shock Proteins
1
2005
2
0.060
Why?
Infant
1
2011
2891
0.060
Why?
Transfection
2
2004
782
0.060
Why?
Child, Preschool
1
2011
3187
0.060
Why?
Ataxin-3
1
2004
4
0.060
Why?
Endosomal Sorting Complexes Required for Transport
1
2004
7
0.060
Why?
HSP40 Heat-Shock Proteins
1
2004
8
0.060
Why?
Protein Structure, Tertiary
2
2004
322
0.060
Why?
Calcium Channels, N-Type
1
2004
7
0.060
Why?
Receptors, GABA-B
1
2004
10
0.060
Why?
Mutagenesis
1
2004
60
0.060
Why?
MAP Kinase Kinase Kinases
1
2004
34
0.060
Why?
Neuroectodermal Tumors, Primitive, Peripheral
1
2004
5
0.060
Why?
Oncogene Proteins, Fusion
1
2004
18
0.060
Why?
Heat-Shock Proteins
1
2004
69
0.060
Why?
Sarcoma, Ewing
1
2004
26
0.060
Why?
Embryo, Mammalian
1
2004
176
0.060
Why?
Oligopeptides
1
2004
152
0.060
Why?
Xenopus Proteins
1
2003
31
0.060
Why?
Repressor Proteins
1
2004
182
0.050
Why?
Phosphoproteins
1
2004
202
0.050
Why?
Sequence Homology, Amino Acid
3
2000
230
0.050
Why?
Graft vs Leukemia Effect
1
2022
33
0.050
Why?
Potassium Channels, Voltage-Gated
1
2002
9
0.050
Why?
Pituitary Gland
1
2002
29
0.050
Why?
Potassium Channel Blockers
1
2002
32
0.050
Why?
rac1 GTP-Binding Protein
1
2002
23
0.050
Why?
rhoA GTP-Binding Protein
1
2002
37
0.050
Why?
Oxidoreductases
1
2022
117
0.050
Why?
Tumor Cells, Cultured
2
1995
852
0.050
Why?
Potassium Channels
1
2002
55
0.050
Why?
Transplantation, Homologous
1
2022
242
0.050
Why?
rac GTP-Binding Proteins
1
2001
8
0.050
Why?
Neural Crest
1
2021
58
0.050
Why?
Neurofibromin 2
1
2001
10
0.050
Why?
Tretinoin
1
2021
92
0.050
Why?
Sympathetic Nervous System
1
2000
81
0.050
Why?
Src Homology 2 Domain-Containing, Transforming Protein 2
2
2000
2
0.050
Why?
Src Homology 2 Domain-Containing, Transforming Protein 3
2
2000
2
0.050
Why?
Microtubule-Associated Proteins
1
2021
114
0.050
Why?
Primary Cell Culture
1
2020
56
0.050
Why?
Zebrafish
1
2021
187
0.050
Why?
Child
1
2011
6401
0.050
Why?
Oocytes
1
2000
57
0.050
Why?
Brain-Derived Neurotrophic Factor
1
2021
124
0.050
Why?
Young Adult
1
2011
5710
0.050
Why?
Tumor Microenvironment
1
2021
213
0.040
Why?
Organ Specificity
2
2000
167
0.040
Why?
Receptors, Nerve Growth Factor
2
1998
20
0.040
Why?
Vascular Endothelial Growth Factor A
1
2021
219
0.040
Why?
Recurrence
1
2022
948
0.040
Why?
Plant Proteins
1
1999
48
0.040
Why?
Copper
1
2020
149
0.040
Why?
Aorta
1
2020
316
0.040
Why?
Adolescent
1
2011
8904
0.040
Why?
Transformation, Genetic
1
1998
14
0.040
Why?
Cell Movement
1
2021
630
0.040
Why?
PC12 Cells
1
1998
36
0.040
Why?
Ganglia, Spinal
1
1998
29
0.040
Why?
Ceramides
1
2022
578
0.040
Why?
Calcium-Calmodulin-Dependent Protein Kinases
1
1998
107
0.040
Why?
T-Lymphocytes
1
2022
597
0.040
Why?
Enzyme Stability
1
2018
30
0.040
Why?
Nerve Growth Factors
1
1998
75
0.040
Why?
Mitogen-Activated Protein Kinase 1
1
1998
150
0.040
Why?
src-Family Kinases
2
2011
91
0.040
Why?
Receptor, ErbB-2
1
1998
128
0.040
Why?
Cell Cycle Proteins
1
1999
230
0.040
Why?
Heterografts
1
2017
70
0.040
Why?
Rats, Sprague-Dawley
2
2018
2083
0.040
Why?
Neoplasm Metastasis
1
2017
306
0.030
Why?
Oxidative Stress
1
2020
718
0.030
Why?
Mammals
1
1996
47
0.030
Why?
Aorta, Thoracic
1
2018
211
0.030
Why?
RNA, Small Interfering
1
2017
434
0.030
Why?
Biopsy
1
2017
539
0.030
Why?
Fibroblasts
1
2020
902
0.030
Why?
Protein Biosynthesis
1
1996
181
0.030
Why?
A Kinase Anchor Proteins
1
2015
7
0.030
Why?
Threonine
1
2015
47
0.030
Why?
Serine
1
2015
99
0.030
Why?
Hydrolysis
1
1995
144
0.030
Why?
Hypoglycemic Agents
1
2018
361
0.030
Why?
Receptors, Adrenergic, beta
1
2015
153
0.030
Why?
Blotting, Northern
2
1991
189
0.030
Why?
Insulin
1
2018
617
0.030
Why?
Hematopoiesis
1
1994
108
0.030
Why?
Cyclic AMP
1
2015
223
0.030
Why?
Tyrosine
1
2015
196
0.030
Why?
RNA, Messenger
3
1996
1663
0.030
Why?
Ligands
1
2015
317
0.030
Why?
Chromosomes, Human, Pair 21
1
2013
9
0.030
Why?
Protein Kinase C
1
1995
270
0.030
Why?
Middle Aged
1
2011
21119
0.030
Why?
Neural Stem Cells
1
2013
32
0.030
Why?
Adult
1
2011
21379
0.030
Why?
Baculoviridae
1
1991
14
0.030
Why?
Blotting, Southern
1
1991
67
0.030
Why?
Fibronectins
1
1991
130
0.020
Why?
Immunoglobulins
1
1991
97
0.020
Why?
RNA, Neoplasm
1
1990
76
0.020
Why?
Calcium-Binding Proteins
1
1990
114
0.020
Why?
Extracellular Matrix Proteins
1
1990
144
0.020
Why?
Breast
1
1990
137
0.020
Why?
Cognition
1
2013
512
0.020
Why?
Tripartite Motif Proteins
1
2009
7
0.020
Why?
Muscle Proteins
1
2009
94
0.020
Why?
Substrate Specificity
1
2009
234
0.020
Why?
Hippocampus
2
2004
471
0.020
Why?
Plasmids
1
2009
258
0.020
Why?
RNA-Binding Proteins
1
2009
215
0.020
Why?
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
1
2009
306
0.020
Why?
RNA-Binding Protein EWS
1
2004
5
0.010
Why?
Focal Adhesion Kinase 2
1
2004
18
0.010
Why?
Precipitin Tests
1
2004
88
0.010
Why?
Electrophysiology
1
2004
160
0.010
Why?
Proto-Oncogene Protein c-fli-1
1
2004
106
0.010
Why?
Chickens
1
2004
232
0.010
Why?
Oligonucleotide Array Sequence Analysis
1
2004
320
0.010
Why?
ERG1 Potassium Channel
1
2002
2
0.010
Why?
Ether-A-Go-Go Potassium Channels
1
2002
3
0.010
Why?
Thyrotropin-Releasing Hormone
1
2002
25
0.010
Why?
Triiodothyronine
1
2002
22
0.010
Why?
Electric Conductivity
1
2002
87
0.010
Why?
cdc42 GTP-Binding Protein
1
2001
20
0.010
Why?
Patch-Clamp Techniques
1
2002
204
0.010
Why?
Breast Neoplasms
1
1990
1533
0.010
Why?
Gene Targeting
1
2000
58
0.010
Why?
Action Potentials
1
2002
223
0.010
Why?
Kinetics
1
2002
1047
0.010
Why?
Proto-Oncogene Proteins c-vav
1
1999
4
0.010
Why?
Calcium
1
2004
929
0.010
Why?
Restriction Mapping
1
1999
85
0.010
Why?
Adaptor Protein Complex alpha Subunits
1
1999
1
0.010
Why?
Adaptor Protein Complex 2
1
1999
3
0.010
Why?
Coated Pits, Cell-Membrane
1
1999
2
0.010
Why?
Dynamins
1
1999
14
0.010
Why?
Sequence Deletion
1
1999
89
0.010
Why?
Genes, Reporter
1
1999
191
0.010
Why?
Xenopus laevis
1
1999
60
0.010
Why?
Phospholipase C gamma
1
1998
13
0.010
Why?
Receptor, trkA
1
1998
13
0.010
Why?
Type C Phospholipases
1
1998
67
0.010
Why?
Cell Line, Transformed
1
1996
100
0.010
Why?
DNA, Complementary
1
1996
251
0.010
Why?
Chick Embryo
1
1996
379
0.010
Why?
Time Factors
1
2004
4655
0.010
Why?
Eye Proteins
1
1996
160
0.010
Why?
RNA-Directed DNA Polymerase
1
1994
11
0.010
Why?
Leukemia, Lymphoid
1
1994
17
0.010
Why?
Myelodysplastic Syndromes
1
1994
24
0.010
Why?
Tetradecanoylphorbol Acetate
1
1994
138
0.010
Why?
Interferon-alpha
1
1994
46
0.010
Why?
Bone Marrow
1
1994
168
0.010
Why?
Monocytes
1
1994
210
0.010
Why?
Flow Cytometry
1
1994
489
0.010
Why?
DNA Probes
1
1990
57
0.010
Why?
Gene Library
1
1990
68
0.010
Why?
Gene Amplification
1
1990
71
0.010
Why?
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